Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30937
Abstract: Obesity‐induced chronic inflammation is a key component in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Increased secretion of proinflammatory cytokines by macrophages in metabolic tissues promotes disease progression. In the diet‐induced… read more here.
Keywords: insulin; inflammation; activation; insulin resistance ... See more keywords
Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes
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DOI: 10.1002/hep.31217
Abstract: Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to… read more here.
Keywords: liver receptor; receptor pathway; hbv infection; pathway inhibits ... See more keywords
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
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DOI: 10.1016/j.ebiom.2018.04.009
Abstract: Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been… read more here.
Keywords: liver ampk; cholesterol; lipid cholesterol; ampk 06409577 ... See more keywords
Inhibition of Human Cytomegalovirus Particle Maturation by Activation of Liver X Receptor
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DOI: 10.3389/fmicb.2022.846386
Abstract: Human cytomegalovirus (HCMV), a herpesvirus family member, is a large, complex enveloped virus. The activation of liver X receptor (LXR) can significantly inhibit the replication of HCMV and weaken the virulence of progeny virus (unpublished… read more here.
Keywords: maturation; hcmv; human cytomegalovirus; activated lxr ... See more keywords
Activation of liver X receptors protects oligodendrocytes in CA3 of stress-induced mice
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DOI: 10.3389/fphar.2022.936045
Abstract: Depression is a complex disorder that is associated with various structural abnormalities. Oligodendrocyte (OL) dysfunction is associated with the pathogenesis of depression and the promotion of hippocampal oligodendrocyte maturation and myelination could be a novel… read more here.
Keywords: stress; activation liver; liver receptors; mice ... See more keywords