Activation of Macrophages in Response to Biomaterials.
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DOI: 10.1007/978-3-319-54090-0_13
Abstract: Macrophages are the initial biologic responders to biomaterials. These highly plastic immune sentinels control and modulate responses to materials, foreign or natural. The responses may vary from immune stimulatory to immune suppressive. Several parameters have… read more here.
Keywords: topography; response; activation macrophages; geometry ... See more keywords
IL‐6 mediates ER expansion during hyperpolarization of alternatively activated macrophages
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DOI: 10.1111/imcb.12212
Abstract: Although recent evidence has shown that IL‐6 is involved in enhanced alternative activation of macrophages toward a profibrotic phenotype, the mechanisms leading to their increased secretory capacity are not fully understood. Here, we investigated the… read more here.
Keywords: ire1 xbp1; expansion; activation macrophages; mediates expansion ... See more keywords
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice
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DOI: 10.15252/embr.202154339
Abstract: Cryopyrin‐associated periodic syndromes (CAPS) are a spectrum of autoinflammatory disorders caused by gain‐of‐function NLRP3 mutant proteins that form hyperactive inflammasomes leading to overproduction of the pro‐inflammatory cytokines IL‐1β and IL‐18. Expressing the murine gain‐of‐function Nlrp3A350V… read more here.
Keywords: activation macrophages; macrophages suffices; autoinflammation; inflammasome activation ... See more keywords
Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis
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DOI: 10.3389/fphar.2017.00975
Abstract: The NLRP3 inflammasome plays a critical role in mediating the innate immune defense against pathogenic infections, but aberrant activation of NLRP3 inflammasome has been linked to a variety of inflammatory diseases. Thus targeting the NLRP3… read more here.
Keywords: sepsis; inflammasome activation; scutellarin; activation macrophages ... See more keywords