Structural aspects and activation mechanism of human secretory group IIA phospholipase
Sign Up to like & getrecommendations! Published in 2020 at "European Biophysics Journal"
DOI: 10.1007/s00249-020-01458-5
Abstract: Phospholipases are important probes for understanding structure–function relationships of membrane proteins. Many neurotoxins have phospholipase activity, and they have been recognized to be potential therapeutic agents for biological warfare. Understanding the modes of action of… read more here.
Keywords: activation mechanism; aspects activation; activation; structural aspects ... See more keywords
Activation of PI3K by Ras: Single Molecule Studies of the Activation Mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2135
Abstract: The lipid-anchored GTPase Ras is well known for its role in oncogenesis – about one quarter of all human tumors show mutations in a Ras family member. One of the best characterized Ras targets is… read more here.
Keywords: activation mechanism; pi3k; single molecule;
SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2021.03.024
Abstract: Coronaviruses have caused multiple epidemics in the past two decades, in addition to the current COVID-19 pandemic that is severely damaging global health and the economy. Coronaviruses employ between twenty and thirty proteins to carry… read more here.
Keywords: activation mechanism; pan coronavirus; pocket; cryptic pocket ... See more keywords
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.12.006
Abstract: The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a… read more here.
Keywords: distinctive activation; activation mechanism; nanobody; angiotensin ... See more keywords
A client-level session-by-session evaluation of behavioral activation's mechanism of action.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of behavior therapy and experimental psychiatry"
DOI: 10.1016/j.jbtep.2016.07.003
Abstract: BACKGROUND AND OBJECTIVES Our understanding of how Behavioral Activation (BA) for depression works is limited. BA is theorized to lead to changes in depression through changes in activation. While distal support for activation as a… read more here.
Keywords: depression; mechanism; behavioral activation; activation mechanism ... See more keywords
Investigating the CO activation mechanism on hcp-Fe7C3 (211) via density functional theory
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2021.111506
Abstract: Abstract The Fischer-Tropsch to Olefins (FTO) process over iron catalysts has attracted interests of academia due to its promising catalytic performance. Several iron carbides phases have been discovered in the spent iron catalysts. Recently, the… read more here.
Keywords: activation; site; fe7c3 211; hcp fe7c3 ... See more keywords
General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02115
Abstract: Under the known pharmacological activation mechanisms, activators allosterically or directly open potassium channel gates. However, herein, molecular dynamics simulations on TREK-1, a member of the channel class gated at the filter, suggested that negatively charged… read more here.
Keywords: pharmacological activation; activation mechanism; channel gates; mechanism ... See more keywords
Exploring the Activation Mechanism of a Metabotropic Glutamate Receptor Homodimer via Molecular Dynamics Simulation.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00425
Abstract: Metabotropic glutamate receptors of class C GPCRs exist as constitutive dimers, which play important roles in activating excitatory synapses of the central nerve system. However, the activation mechanism induced by agonists has not been clarified… read more here.
Keywords: molecular dynamics; activation mechanism; metabotropic glutamate; dynamics simulation ... See more keywords
Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04808
Abstract: Prodrugs have little or no pharmacological activity and are converted to active drugs in the body by enzymes, metabolic reactions, or through human-controlled actions. However, prodrugs promoting their chemical bioconversion without any of these processes… read more here.
Keywords: trna synthetase; adenosine dependent; activation mechanism; dependent activation ... See more keywords
Characterization of the ExoU activation mechanism using EPR and integrative modeling
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76023-3
Abstract: ExoU, a type III secreted phospholipase effector of Pseudomonas aeruginosa, serves as a prototype to model large, dynamic, membrane-associated proteins. ExoU is synergistically activated by interactions with membrane lipids and ubiquitin. To dissect the activation… read more here.
Keywords: activation mechanism; activation; mechanism using; exou activation ... See more keywords
New activation mechanism for half-sandwich organometallic anticancer complexes† †Electronic supplementary information (ESI) available. CCDC 1420046–1420052 and 1569283. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc05058e
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc05058e
Abstract: Half-sandwich RhIII anticancer complexes with activated Cp* rings not only undergo sequential CH3 H–D exchange, but also react with biological dienes, generating RhI Diels–Alder adducts in aqueous media at ambient temperature. read more here.
Keywords: activation mechanism; half sandwich; anticancer complexes; new activation ... See more keywords