Activation mechanisms of the first sphingosine‐1‐phosphate receptor
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3165
Abstract: Activation of the first sphingosine‐1‐phosphate receptor (S1PR1) promotes permeability of the blood brain barrier, astrocyte and neuronal protection, and lymphocyte egress from secondary lymphoid tissues. Although an agonist often activates the S1PR1, the receptor exhibits… read more here.
Keywords: first sphingosine; activation mechanisms; sphingosine phosphate; activation ... See more keywords
Review: Structure and Activation Mechanisms of CRAC Channels.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_23
Abstract: Ca2+ release activated Ca2+ (CRAC) channels represent a primary pathway for Ca2+ to enter non-excitable cells. The two key players in this process are the stromal interaction molecule (STIM), a Ca2+ sensor embedded in the… read more here.
Keywords: structure; crac channels; ca2; activation mechanisms ... See more keywords
Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.015
Abstract: Ruthenium (Ru) complexes are known for their promising anticancer activity presumably due to octahedral coordination geometry, slow ligand exchange rate, the range of different oxidation states and target specificity. This review article summarizes the physicochemical… read more here.
Keywords: ruthenium; coordination; detailed account; activation mechanisms ... See more keywords
Distinguishing Among All Possible Activation Mechanisms of a Plasmon-Driven Chemical Reaction
Sign Up to like & getrecommendations! Published in 2020 at "ACS energy letters"
DOI: 10.1021/acsenergylett.0c00989
Abstract: Localized surface plasmon resonances (LSPRs) in metal nanoparticles can drive chemical reactions at their surface, but it is often challenging to disentangle the exact activation mechanism. The decay of LSPRs can lead to photothermal heating,… read more here.
Keywords: distinguishing among; possible activation; among possible; activation mechanisms ... See more keywords
Differential activation mechanisms of two isoforms of Gcr1 transcription factor generated from spliced and un-spliced transcripts in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1221
Abstract: Abstract Gcr1, an important transcription factor for glycolytic genes in Saccharomyces cerevisiae, was recently revealed to have two isoforms, Gcr1U and Gcr1S, produced from un-spliced and spliced transcripts, respectively. In this study, by generating strains… read more here.
Keywords: saccharomyces cerevisiae; two isoforms; spliced spliced; activation mechanisms ... See more keywords
Activation mechanisms of inflammasomes by bacterial toxins
Sign Up to like & getrecommendations! Published in 2021 at "Cellular Microbiology"
DOI: 10.1111/cmi.13309
Abstract: Inflammasomes are cytosolic innate immune complexes, which assemble in mammalian cells in response to microbial components and endogenous danger signals. A major family of inflammasome activators is bacterial toxins. Inflammasome sensor proteins, such as the… read more here.
Keywords: mechanisms inflammasomes; family; activation mechanisms; microbiology ... See more keywords
Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/8695157
Abstract: A variety of receptors perform the function of attenuating or inhibiting activation of cells in which they are expressed. Examples of these kinds of receptors include TIM-3 and PD-1, among others that have been widely… read more here.
Keywords: macrophage activation; tolerance; inhibit macrophage; activation mechanisms ... See more keywords
Activation mechanisms of monocytes/macrophages in adult-onset Still disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.953730
Abstract: Adult onset Still disease (AOSD) is a systemic inflammatory disorder characterized by skin rash, spiking fever, arthritis, sore throat, lymphadenopathy, and hepatosplenomegaly. Although the etiology of this disease has not been fully clarified, both innate… read more here.
Keywords: mechanisms monocytes; monocytes macrophages; adult onset; activation mechanisms ... See more keywords
From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.796229
Abstract: With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the… read more here.
Keywords: mechanisms proton; proton conduction; proton channel; activation mechanisms ... See more keywords
Activation Mechanisms and Diverse Functions of Mammalian Phospholipase C
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13060915
Abstract: Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by metabolizing phosphatidylinositol 4,5-bisphosphate in the plasma membrane. This process generates two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol, which respectively regulate the intracellular Ca2+… read more here.
Keywords: phospholipase; activation mechanisms; plc; mechanisms diverse ... See more keywords