Downregulation of USP4 Promotes Activation of Microglia and Subsequent Neuronal Inflammation in Rat Spinal Cord After Injury
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DOI: 10.1007/s11064-017-2361-2
Abstract: NF-κB is involved in the activation of microglia, which induces secondary spinal cord injury (SCI). This process involves the activation of NF-κB signaling pathway by TRAF6 through its polyubiquitination function. We know that deubiquitination of… read more here.
Keywords: neuronal inflammation; activation microglia; expression; activation ... See more keywords
Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlad006
Abstract: Neuropathic pain (NP) is pain caused by injury or dysfunction of the somatosensory system. The role of Rac2, a member of the Rac family, which is expressed in neutrophils, macrophages, and adult T cells, in… read more here.
Keywords: inflammatory response; activation microglia; apoptosis; expression ... See more keywords
Pro‐inflammatory activation of microglia in the brain of patients with sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12502
Abstract: Experimental data suggest that systemic immune activation may create a pro‐inflammatory environment with microglia activation in the central nervous system in the absence of overt inflammation, which in turn may be deleterious in conditions of… read more here.
Keywords: inflammatory activation; activation microglia; activation; microglia brain ... See more keywords
Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314701
Abstract: The excessive activation of microglia cell induced by adolescent intermittent ethanol (AIE) leads to neuroinflammation in the hippocampus. The endocannabinoid system plays a key role in the modulation of microglia activation. Accumulating evidence suggests that… read more here.
Keywords: activation microglia; treadmill exercise; hippocampus; excessive activation ... See more keywords
The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways
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DOI: 10.3390/ijms24054739
Abstract: Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their ability to survey, assess and respond to perturbations in their local environment is critical in their role of maintaining CNS homeostasis in… read more here.
Keywords: activation microglia; modulated sexually; pathological activation; microglia modulated ... See more keywords
Severity- and Time-Dependent Activation of Microglia in Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098294
Abstract: A spinal cord injury (SCI) initiates a number of cascades of biochemical reactions and intercellular interactions, the outcome of which determines the regenerative potential of the nervous tissue and opens up capacities for preserving its… read more here.
Keywords: sci; activation microglia; cord injury; severity ... See more keywords