Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration
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DOI: 10.1161/hypertensionaha.121.18643
Abstract: Background: The present study in Sprague-Dawley rats determined the effects of a rapid rise of renal perfusion pressure (RPP) upon the activation of mTOR (mechanistic target of rapamycin), and the effects upon the infiltration of… read more here.
Keywords: infiltration; rpp; activation mtorc1; increase ... See more keywords
Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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DOI: 10.15252/embr.201949898
Abstract: Nutrient sensing by the mTOR complex 1 (mTORC1) requires its translocation to the lysosomal membrane. Upon amino acids removal, mTORC1 becomes cytosolic and inactive, yet its precise subcellular localization and the mechanism of inhibition remain… read more here.
Keywords: activation mtorc1; aster; mtorc1; cop vesicles ... See more keywords