Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4332
Abstract: Nitrosamines were a class of important environmental carcinogens associated with digestive tract neoplasms. As the early toxic effect of nitrosamines, inflammatory response participated in the malignant transformation of cells and promoted the occurrence and development… read more here.
Keywords: reactive oxygen; activation nlrp3; oxygen species; exposure ... See more keywords
Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-10087-7
Abstract: Interleukin (IL)-1β and IL-18 are involved in the inflammatory response of wear-induced osteolysis. The production and secretion of these interleukins are regulated by the nucleotide-binding oligomerization domain leucine-rich repeat-containing protein (NLRP3) inflammasome. Uptake of wear… read more here.
Keywords: activation; nlrp3 inflammasome; activation nlrp3; human osteoblasts ... See more keywords
Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.02.014
Abstract: Epidemiological studies showed a strong association between alcoholism and incidence of stroke, for which the underlying causative mechanisms remain to be understood. Here we found that infiltration of immune cells and deposition of cholesterol at… read more here.
Keywords: cholesterol; activation nlrp3; atherosclerotic lesions; activation ... See more keywords
MicroNAR-194-5p hinders the activation of NLRP3 inflammasomes and alleviates neuroinflammation during intracerebral hemorrhage by blocking the interaction between TRAF6 and NLRP3
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147228
Abstract: The possible role of miR-194-5p in brain and neurodegenerative diseases has been reported, but its role in intracerebral hemorrhage (ICH) has not been studied. This study estimated the mechanism of miR-194-5p in ICH. ICH rat… read more here.
Keywords: traf6 nlrp3; traf6; nlrp3 inflammasomes; activation nlrp3 ... See more keywords
Piperine ameliorated lupus nephritis by targeting AMPK‐mediated activation of NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.10.025
Abstract: Background: Lupus nephritis (LN) is a leading cause of mortality. The activation of NLRP3 inflammasome contributed to LN development and thus became a therapeutic target. Here we assessed the therapeutic potential of piperine, a bioactive… read more here.
Keywords: activation nlrp3; lupus nephritis; piperine; activation ... See more keywords
Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of helminthology"
DOI: 10.1017/s0022149x19000622
Abstract: Schistosomiasis is an inflammatory disease that occurs when schistosome species eggs are deposited in the liver, resulting in fibrosis and portal hypertension. Schistosomes can interact with host inflammasomes to elicit host immune responses, leading to… read more here.
Keywords: activation; activation nlrp3; mansoni infection; schistosoma mansoni ... See more keywords
Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-04823-6
Abstract: In this study, we retrospectively analyzed whether serum lactate levels were elevated in patients with schizophrenia (SCZ) and explored cognitive deficits, abnormalities in lactate metabolism, and neuroinflammation in an dizocilpine (MK-801)-induced N-methyl-d-aspartate (NMDA) receptor (NMDAR)… read more here.
Keywords: activation nlrp3; lactate; pathway; serum lactate ... See more keywords
Acupuncture at ST36 Alleviates the Behavioral Disorder of Autistic Rats by Inhibiting TXNIP-Mediated Activation of NLRP3.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab132
Abstract: Autism is a common neurodevelopmental disorder that severely affects patients' quality of life. We aimed to investigate whether acupuncture at Zusanli (ST36) could alleviate the behavior disorder of autistic rats by inhibiting thioredoxin-interacting protein (TXNIP)-mediated… read more here.
Keywords: autistic rats; txnip; activation nlrp3; acupuncture ... See more keywords
Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oral Microbiology"
DOI: 10.1111/omi.12225
Abstract: The NLRP3 inflammasome, an intracellular sensor consisting of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and procaspase-1, plays critical roles… read more here.
Keywords: nlrp3 asc; inflammasome macrophages; production; activation nlrp3 ... See more keywords
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abm7134
Abstract: Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigger inflammasome formation and inflammatory… read more here.
Keywords: activation nlrp3; endosomal trafficking; endosome trafficking; traffic ... See more keywords
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/2640209
Abstract: San-Huang-Yi-Shen capsule (SHYS) has been used in the treatment of diabetic kidney disease (DKD) in clinics. However, the mechanism of SHYS on DKD remains unclear. In this study, we used a high-fat diet combined with… read more here.
Keywords: pink1 parkin; mediated mitophagy; activation nlrp3; parkin mediated ... See more keywords