tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11849
Abstract: The respiratory system is always exposed to air and is most vulnerable to attack by environmental free radicals. The nuclear factor E2‐related factor 2–Kelch‐like ECH‐associated protein 1–antioxidant response element (Nrf2‐Keap1‐ARE) pathway and p62 are both… read more here.
Keywords: tert butylhydroquinone; keap1 pathway; nrf2 keap1; p62 ... See more keywords
FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23295
Abstract: Incidence of melanoma continues to rise in the United States with ~100,000 new cases diagnosed in 2019. While the 5‐year survival rate of melanoma is 99% when localized, the rate of survival drops to 22.5%… read more here.
Keywords: melanoma; mutant melanoma; braf; melanoma cells ... See more keywords
Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cell and Tissue Research"
DOI: 10.1007/s00441-018-2877-z
Abstract: Sulforaphane (SFN) has been considered as an indirect antioxidant and potential inducer of the Nrf2-ARE pathway. This study was conducted to investigate the protective role of SFN against oxidative stress in bovine granulosa cells (GCs).… read more here.
Keywords: granulosa cells; nrf2 pathway; group; activation nrf2 ... See more keywords
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2017.12.015
Abstract: Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor boosting… read more here.
Keywords: natural products; nrf2 signaling; activation nrf2; alleviate diabetes ... See more keywords
Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06216
Abstract: The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) play a crucial role in cellular redox and metabolic system. Activation of Nrf2 may be an effective therapeutic approach for neuroinflammatory disorders, through activation of… read more here.
Keywords: nrf2 pathway; neuroinflammatory disorders; activation nrf2; natural antioxidants ... See more keywords
Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: A promising therapeutic strategy for hepatic fibrosis - A review.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117909
Abstract: Hepatic fibrosis (HF) is a wound-healing response that occurs during chronic liver injury and features by an excessive accumulation of extracellular matrix (ECM) components. Activation of hepatic stellate cell (HSC), the leading effector in HF,… read more here.
Keywords: nrf2 ares; pathway; activation nrf2; tgf ... See more keywords
Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101271
Abstract: Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular response to oxidative stress. We evaluated the impact… read more here.
Keywords: pharmacological activation; dysfunction; activation nrf2; vascular dysfunction ... See more keywords
Activation of Nrf2 decreases bile acid concentrations in livers of female mice
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1880033
Abstract: Abstract 1. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of oxidative/electrophilic stress. Studies suggest a role of Nrf2 in regulating bile acid (BA) metabolism in male mice. However, whether Nrf2 is important… read more here.
Keywords: female mice; activation nrf2; bile acid; activation ... See more keywords
Betanin ameliorates fipronil-induced nephrotoxicity via activation of Nrf2-HO-1/NQO-1 pathway in albino rat model.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac076
Abstract: Fipronil (FPN) is phenylpyrazole insecticide extensively used to control a wide variety of pests. Betanin (BET) is a natural colorant with promising antioxidant and anti-inflammatory effects. This study aimed to investigate the potential protective effect… read more here.
Keywords: induced nephrotoxicity; nrf2 nqo; via activation; group ... See more keywords
Sulforaphane prevents angiotensin II‐induced cardiomyopathy by activation of Nrf2 through epigenetic modification
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16504
Abstract: Nuclear factor erythroid 2‐related factor (Nrf2) is an important regulator of cellular antioxidant defence. We previously showed that SFN prevented Ang II‐induced cardiac damage via activation of Nrf2. However, the underlying mechanism of SFN’s persistent… read more here.
Keywords: epigenetic modification; ang induced; nrf2 epigenetic; activation nrf2 ... See more keywords
Activation of Nrf2 signaling protects hypoxia‐induced HTR‐8/SVneo cells against ferroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15009
Abstract: This article aims to investigate the possible mechanism by which nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling exerts protective effects on the progression of preeclampsia (PE). read more here.
Keywords: nrf2 signaling; activation nrf2; induced htr; signaling protects ... See more keywords