Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
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DOI: 10.1016/j.ejphar.2019.172497
Abstract: Metformin, an AMP-activated protein kinase (AMPK) activator, is an oral hypoglycemic drug widely used to treat patients with type 2 diabetes. As AMPK plays a role in the nociceptive processing, investigating the effects induced by… read more here.
Keywords: activation opioidergic; metformin; nociceptive neuropathic; neuropathic pain ... See more keywords