Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy
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DOI: 10.1126/sciadv.abk0052
Abstract: FLNC truncating mutations (FLNCtv) are prevalent causes of inherited dilated cardiomyopathy (DCM), with a high risk of developing arrhythmogenic cardiomyopathy. We investigated the molecular mechanisms of mutant FLNC in the pathogenesis of arrhythmogenic DCM (a-DCM)… read more here.
Keywords: pdgfra signaling; activation pdgfra; ipsc cms; arrhythmogenic cardiomyopathy ... See more keywords