Site‐specific functional roles of the Factor X activation peptide in the intrinsic tenase‐mediated Factor X activation
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DOI: 10.1002/1873-3468.14321
Abstract: The conversion of zymogen Factor X (FX) to an active protease involves the removal of a 52‐residue long activation peptide (AP). Through site‐directed mutagenesis, we investigate the role of the AP and demonstrate that the… read more here.
Keywords: intrinsic tenase; factor activation; factor; site ... See more keywords
Role of the activation peptide in the mechanism of protein C activation
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DOI: 10.1038/s41598-020-68078-z
Abstract: Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease conversion of protein C involves removal of a short activation peptide that, relative to… read more here.
Keywords: protein; role activation; acidic residues; activation ... See more keywords
Evolutionary Adaptations in Pseudonaja Textilis Venom Factor X Induce Zymogen Activity and Resistance to the Intrinsic Tenase Complex.
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DOI: 10.1055/s-0040-1715441
Abstract: The venom of the Australian snake Pseudonaja textilis comprises powerful prothrombin activators consisting of factor X (v-ptFX)- and factor V-like proteins. While all vertebrate liver-expressed factor X (FX) homologs, including that of P. textilis, comprise… read more here.
Keywords: venom; activation; factor; tenase complex ... See more keywords