Insight into the mechanism of allosteric activation of PI3Kα by oncoprotein K-Ras4B.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.020
Abstract: Ras is a key member in the superfamily of small GTPase. Transforming between GTP-bound active state and GDP-bound inactive state in response to exogenous signals, Ras serves as a binary switch in various signaling pathways.… read more here.
Keywords: state; pi3k; ras4b; activation pi3k ... See more keywords
Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.01.010
Abstract: Class I phosphoinositide-3-kinases (PI3Ks) phosphorylate PIP2 at its 3' inositol position to generate PIP3, a second messenger that influences signaling cascades regulating cellular growth, survival, and proliferation. Previous studies have suggested that PI3Kα activation involves… read more here.
Keywords: pi3k; activation pi3k; allosteric activation; nsh2 domain ... See more keywords
Proteinase-activated receptor 2 promotes 3T3-L1 preadipocyte differentiation through activation of the PI3K/AKT signalling pathway and MAT2A gene expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2020.1817094
Abstract: Abstract The present study aimed to investigate the function and mechanisms of PAR2 in preadipocyte differentiation. This study found that the expression level of PAR2 was increased during 3T3-L1 mouse preadipocyte differentiation towards adipocytes. In… read more here.
Keywords: pi3k akt; preadipocyte differentiation; expression; differentiation ... See more keywords
Activation of PI3K/Akt prevents hypoxia/reoxygenation-induced GnRH decline via FOXO3a.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological research"
DOI: 10.33549/physiolres.934861
Abstract: Recent studies have suggested that the hypothalamus has an important role in aging by regulating nuclear factor-?B (NF-?B)-directed gonadotropin-releasing hormone (GnRH) decline. Moreover, our previous study has shown that ischemia-reperfusion (IR) injury activates NF-?B to… read more here.
Keywords: decline; pi3k akt; activation pi3k; hypoxia reoxygenation ... See more keywords