Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53
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DOI: 10.1158/0008-5472.can-19-1912
Abstract: These findings identify hypomethylation-mediated activation of PLCE1 as a potential oncogene that blocks cellular autophagy of esophageal carcinoma by facilitating the MDM2-dependent ubiquitination of p53 and subsequent degradation. Esophageal squamous cell carcinoma (ESCC) is one… read more here.
Keywords: plce1; hypomethylation; ubiquitination; activation plce1 ... See more keywords