Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0401-y
Abstract: Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puerarin, a phytoestrogen, exerts beneficial effects on cardiac function… read more here.
Keywords: cardiac hypertrophy; puerarin; pgc pathway; hypertrophy ... See more keywords
PPAR control of metabolism and cardiovascular functions
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DOI: 10.1038/s41569-021-00569-6
Abstract: Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription factors that regulate gene expression following ligand activation. PPARα increases cellular fatty acid uptake, esterification and trafficking, and regulates lipoprotein metabolism genes. PPARδ stimulates lipid and… read more here.
Keywords: ppar; ppar ppar; heart; metabolism ... See more keywords
Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173676
Abstract: Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPARα may be activated. Here we report a reduced autophagic capacity in the liver following chronic… read more here.
Keywords: ppar; autophagic proteins; chronic activation; ppar fenofibrate ... See more keywords