Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction.
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DOI: 10.1093/intimm/dxac028
Abstract: The Nod-like receptor family pyrin domain containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic, and drug stresses. Upon activation, NLRP3 forms… read more here.
Keywords: activation preventing; dysfunction; inflammasome activation; inhibits nlrp3 ... See more keywords