Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy
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DOI: 10.1038/s41598-021-94298-y
Abstract: Canakinumab is a fully human monoclonal antibody that specifically neutralizes human interleukin (IL)-1β and has been approved by the US Food and Drug Administration for treating different types of autoinflammatory disorders such as cryopyrin-associated periodic… read more here.
Keywords: selective activation; antibody; canakinumab; autoinflammatory ... See more keywords
Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis
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DOI: 10.3390/ijms20163845
Abstract: In chronic inflammatory joint diseases, such as rheumatoid arthritis, there is an important bone loss. Parathyroid hormone-related protein (PTHrP) and related peptides have shown osteoinductive properties in bone regeneration models, but there are no data… read more here.
Keywords: induced arthritis; immune activation; collagen induced; activation ... See more keywords