[68Ga]FAPI PET/CT reveals increased pulmonary fibroblast activation protein expression in long COVID patients after ICU discharge
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07376-y
Abstract: Post-acute sequelae of COVID-19 (PASC) has emerged as a major healthcare problem. A comprehensive mechanism of disease remains to be elucidated. In this study we aimed to explore pulmonary and muscle fibroblast activation protein (FAP)… read more here.
Keywords: covid patients; fibroblast activation; 68ga fapi; activation protein ... See more keywords
Quantification of the immunohistochemical staining of fibroblast activation protein in intrathoracic solitary fibrous tumors using QuPath
Sign Up to like & getrecommendations! Published in 2025 at "Surgery Today"
DOI: 10.1007/s00595-025-03024-y
Abstract: Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that can develop in the pleura. In the past, SFTs were considered benign, but there have been reports of SFTs being highly malignant. Fibroblast activation protein (FAP)… read more here.
Keywords: solitary fibrous; immunohistochemical staining; fibrous tumors; fibroblast activation ... See more keywords
Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein
Sign Up to like & getrecommendations! Published in 2017 at "Protoplasma"
DOI: 10.1007/s00709-017-1129-5
Abstract: The importance of the dipeptidyl peptidase 4 (DPP4) gene family in regulating critical biochemical pathways continues to emerge. The two most well-studied members of the family, DPP4 and fibroblast activation protein (FAP), have been investigated… read more here.
Keywords: disease biomarkers; disease; potential disease; activation protein ... See more keywords
A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-α (FAPα)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01593-1
Abstract: Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable imaging of multiple human cancers, but time-dependent clearance… read more here.
Keywords: fap; rps 309; activation protein; ligand ... See more keywords
The Role of Fibroblast Activation Protein Ligands in Oncologic PET Imaging.
Sign Up to like & getrecommendations! Published in 2021 at "PET clinics"
DOI: 10.1016/j.cpet.2021.03.012
Abstract: Fibroblast activation protein inhibitor emerges as a novel and highly promising agent for diagnostic and possibly theranostic application in various malignant and non-malignant diseases. FAPI impresses with its selective expression in several pathologies, ligand induced… read more here.
Keywords: activation protein; role fibroblast; fibroblast activation;
Bioluminescent Probe for Monitoring Endogenous Fibroblast Activation Protein Alpha.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02117
Abstract: Fibroblast activation protein-α (FAP), as a crucial member of cell surface glycoprotein, highly expresses in reactive fibroblasts of tumors and several fibrosis diseases. It is a potential target for drug design and also reported as… read more here.
Keywords: activation protein; fibroblast activation; bioluminescent probe; probe ... See more keywords
The Activation of Protein Kinase A by the Calcium-Binding Protein S100A1 Is Independent of Cyclic AMP
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00117
Abstract: Biochemical and structural studies demonstrate that S100A1 is involved in a Ca2+-dependent interaction with the type 2α and type 2β regulatory subunits of protein kinase A (PKA) (RIIα and RIIβ) to activate holo-PKA. The interaction… read more here.
Keywords: calcium binding; kinase calcium; activation protein; binding protein ... See more keywords
Receptor-Mediated Transmembrane Activation of Protein Folding in Synthetic Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.5c00043
Abstract: Synthetic cells are a rapidly maturing platform with emerging applications in biomedicine and biotechnology. The specific novelty of this work is that we develop synthetic cells that respond to an extracellular stimulus by performing the… read more here.
Keywords: transmembrane activation; receptor mediated; protein folding; synthetic cells ... See more keywords
Synthesis and Preclinical Evaluation of Druglike 18F-Labeled Fibroblast Activation Protein (FAP) Inhibitors with Enhanced Tumor Retention.
Sign Up to like & getrecommendations! Published in 2025 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.5c00366
Abstract: Fibroblast activation protein (FAP) is upregulated in cancer and fibrosis, making it an ideal target for imaging and therapy. Most FAP radioligands are large, highly polar, chelator-based molecules that suffer from limited tissue penetration and… read more here.
Keywords: fibroblast activation; protein fap; tumor retention; tumor ... See more keywords
Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting the Fibroblast Activation Protein.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02162
Abstract: The fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAFs), has become a valuable target for tumor diagnosis and therapy. However, most FAP-based radioligands show insufficient tumor uptake and retention. In this study, three novel… read more here.
Keywords: activation protein; protein binding; fibroblast activation; tumor ... See more keywords
Druglike, 18F-labeled PET Tracers Targeting Fibroblast Activation Protein.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c02402
Abstract: Fibroblast activation protein (FAP) is a very reliable biomarker for tissue remodeling. FAP has so far mainly been studied in oncology, but there is growing interest in the enzyme in other diseases like fibrosis. Recently,… read more here.
Keywords: oncology; fibroblast activation; activation protein; 18f labeled ... See more keywords