Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01019-z
Abstract: Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar over respiration. We now reveal an evolutionary conserved mechanism linking fermentation to activation of Ras, a major regulator of cell proliferation in… read more here.
Keywords: fructose bisphosphate; fru1 6bisp; activation ras; yeast ... See more keywords
Abstract PR04: Small molecule-mediated activation of Ras elicits inhibition of MAPK and PI3K signaling though pathway feedback
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-pr04
Abstract: Oncogenic mutation or hyper-activation of Ras results in aberrant cellular signaling and is responsible for approximately 30% of all human tumors. Therefore, Ras is an outstanding candidate for therapeutic inhibition. However, the discovery of potent… read more here.
Keywords: pi3k; mapk pi3k; inhibition; activation ras ... See more keywords