Insights image for Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages
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DOI: 10.1038/s41390-019-0544-z
Abstract: Nigericin activates the NLRP3 inflammasome by stimulating an intracellular K+ efflux through the pannexin-1 dependent pathway, which induces the assembly of the NLRP3 inflammasome (NLRP3-ASC-Caspase 1) and its subsequent activation of the secretion of IL-1β… read more here.
Keywords: caspase; insights image; secretion; activation secretion ... See more keywords