Quantitative Determination and Imaging of Gαq Signaling in Live Cells via Split-Luciferase Complementation.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_7
Abstract: G Protein-coupled receptors (GPCRs) transduce signals elicited by bioactive chemical agents (ligands), such as hormones, neurotransmitters, or cytokines, across the cellular membrane. Upon ligand binding, the receptor undergoes structural rearrangements, which cause the activation of… read more here.
Keywords: split luciferase; live cells; activation signaling; luciferase complementation ... See more keywords
lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer"
DOI: 10.1186/s12943-020-01153-1
Abstract: The activation of NF-κB signaling pathway is regarded as the dominant process that correlates with tumorigenesis. Recently, increasing evidence shows that long noncoding RNAs (lncRNAs) play crucial roles in sustaining the NF-κB signaling pathway. However,… read more here.
Keywords: positive feedback; plact1; pdac; signaling pathway ... See more keywords
SYTL5 promotes papillary thyroid carcinoma progression by enhancing activation of the NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac187
Abstract: The function and mechanism of SYTL5 in papillary thyroid carcinoma (PTC) are still unclear. In this research, we found that SYTL5 was significantly overexpressed in PTC tissues compared with normal thyroid tissues. SYTL5 downregulation significantly… read more here.
Keywords: thyroid carcinoma; signaling pathway; progression; sytl5 ... See more keywords
Structural insights into the assembly and activation of the IL‐27 signaling complex
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202255450
Abstract: Interleukin 27 (IL‐27) is a heterodimeric cytokine that elicits potent immunosuppressive responses. Comprised of EBI3 and p28 subunits, IL‐27 binds GP130 and IL‐27Rα receptor chains to activate the JAK/STAT signaling cascade. However, how these receptors… read more here.
Keywords: cytokine; structural insights; assembly activation; signaling complex ... See more keywords
Activation of the NFκB signaling pathway in IL6+CSF3+ vascular endothelial cells promotes the formation of keloids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.917726
Abstract: Background: Keloid is a disease caused by abnormal proliferation of skin fibres, the causative mechanism of which remains unclear. Method: In this study, endothelial cells of keloids were studied using scRNAseq combined with bulk-RNAseq data… read more here.
Keywords: cell; signaling pathway; endothelial cells; endothelial cell ... See more keywords
The Activation and Signaling Mechanisms of GPR56/ADGRG1 in Melanoma Cell
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00304
Abstract: Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest GPCR subfamily. GPR56/ADGRG1 is a member of the ADGRG subgroup of aGPCRs. Although GPR56 is best known for its pivotal role in the cerebral cortical development,… read more here.
Keywords: melanoma; gpr56 adgrg1; mechanisms gpr56; signaling mechanisms ... See more keywords
SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Letters"
DOI: 10.3892/ol.2023.13832
Abstract: Cervical cancer (CC) is the most common human papillomavirus-related disease. Continuous activation of the NF-κB signaling pathway has been observed in CC. SHC binding and spindle associated 1 (SHCBP1) contributes to tumorigenesis and activation of… read more here.
Keywords: cervical cancer; shcbp1 contributes; signaling pathway; cancer ... See more keywords