The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain
Sign Up to like & getrecommendations! Published in 2020 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2019.116342
Abstract: Quantitative functional magnetic resonance imaging methods make it possible to measure cerebral oxygen metabolism (CMRO2) in the human brain. Current methods require the subject to breathe special gas mixtures (hypercapnia and hyperoxia). We tested a… read more here.
Keywords: gas; human brain; oxygen metabolism; activation ... See more keywords
Comment on “Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases”
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abm8302
Abstract: Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent modulation of FDG-PET. Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent… read more here.
Keywords: comment microglial; fdg; activation states; microglial activation ... See more keywords
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00453-4
Abstract: Introduction Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of preexisting Aβ deposition and the… read more here.
Keywords: immune activation; immunotherapy; activation states; transcriptomic data ... See more keywords
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00176
Abstract: Parkinson’s disease (PD) is a chronic and progressive disorder characterized neuropathologically by loss of dopamine neurons in the substantia nigra, intracellular proteinaceous inclusions, reduction of dopaminergic terminals in the striatum, and increased neuroinflammatory cells. The… read more here.
Keywords: activation; parkinson disease; activation states; targeting microglial ... See more keywords