Activation of STING signaling accelerates skin wound healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.11.008
Abstract: BACKGROUND The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of… read more here.
Keywords: wound healing; skin wound; cgamp; sting signaling ... See more keywords
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc01896b
Abstract: Controllable activation of the innate immune adapter protein – stimulator of interferon genes (STING) pathway is a critical challenge for the clinical development of STING agonists due to the potential “on-target off-tumor” toxicity caused by… read more here.
Keywords: cell growth; tumor cell; tumor; activation ... See more keywords
Abstract 631: Intratumoral activation of STING with a synthetic cyclic dinucleotide elicits antitumor CD8 T-cell immunity that effectively combines with checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-631
Abstract: Activation of the STING pathway by intratumoral (IT) injection of synthetic cyclic dinucleotides (CDNs) induces stable tumor regression in preclinical models, yet the underlying immune correlates are not fully understood. ADU-S100, a CDN under clinical… read more here.
Keywords: cd8 cell; immunity; activation; activation sting ... See more keywords