An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein
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DOI: 10.1073/pnas.2404457121
Abstract: Significance FTO is an RNA demethylase of the Alkb family of dioxygenases involved in regulation of gene expression and development of metabolic diseases such as obesity and cancer. Given its central role, extensive effort has… read more here.
Keywords: conformational switch; activation substrate; fto; substrate ... See more keywords