Catalytic Activation of Thioglycosides with Copper-Carbenes for Stereoselective 1,2-Cis-Furanosylations.
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DOI: 10.1021/acs.orglett.4c03281
Abstract: Thioglycoside activation, crucial for oligosaccharide synthesis, faces challenges with the need for stoichiometric promoters, additives, and cryogenic conditions, particularly in stereoselective 1,2-cis-linkage formation. This study introduces a carbene-based catalytic method using Cu(OTf)2 for thioglycoside activation,… read more here.
Keywords: stereoselective cis; catalytic activation; thioglycosides copper; activation thioglycosides ... See more keywords