Synergistic anti‐inflammatory effects of quercetin and catechin via inhibiting activation of TLR4–MyD88‐mediated NF‐κB and MAPK signaling pathways
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DOI: 10.1002/ptr.6268
Abstract: The synergistic anti‐inflammatory effect of quercetin and catechin was investigated using lipopolysaccharide (LPS)‐stimulated macrophage RAW 264.7 cells. Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS‐stimulated increase of some proinflammatory molecules,… read more here.
Keywords: anti inflammatory; quercetin catechin; synergistic anti; tlr4 myd88 ... See more keywords
Activation of TLR4 of Mesenchymal Stem Cells Enhances the Regenerative Properties of Their Secretomes
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DOI: 10.1007/s10517-021-05103-9
Abstract: Mesenchymal stem cells (MSC), like macrophages, can be polarized in vitro . In particular, activation of type 4 Toll-like receptor in MSC leads to the appearance of the so-called “proinflammatory” MSC phenotype (MSC1). We showed… read more here.
Keywords: msc; stem cells; activation tlr4; mesenchymal stem ... See more keywords
Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway
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DOI: 10.1080/21655979.2022.2070996
Abstract: ABSTRACT As a multifactorial disease, intervertebral disc degeneration (IVDD) causes many spinal-related diseases, which causes disability in the workforce and heavy social costs all over the world. Recently, Ganoderic Acid A (GAA) has been reported… read more here.
Keywords: activation tlr4; nlrp3 signaling; ganoderic acid; intervertebral disc ... See more keywords
Carvacrol Ameliorates DSS-Induced Intestinal Inflammation in Rats by Suppressing the TLR4/NF-κB Pathway
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DOI: 10.1177/1934578x221130147
Abstract: The present study aimed to explore the therapeutic effects of carvacrol on the ulcerative colitis (UC) inflammation model induced by DSS (dextran sulfate sodium) in rats. Forty rats were randomly divided into the blank, model,… read more here.
Keywords: carvacrol; inflammation; activation tlr4; model ... See more keywords
Activation of TLR4 by viral glycoproteins: A double-edged sword?
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DOI: 10.3389/fmicb.2022.1007081
Abstract: Recognition of viral infection by pattern recognition receptors is paramount for a successful immune response to viral infection. However, an unbalanced proinflammatory response can be detrimental to the host. Recently, multiple studies have identified that… read more here.
Keywords: activation tlr4; tlr4 viral; viral glycoproteins; virus ... See more keywords