Awakening Allies for Breaking Microenvironment Barriers: NIR-II Guided Orthogonal Activation of Tumor-infiltrating Mast Cells for Efficient Nano-drug Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300420
Abstract: Mast cells (MCs), powerful immune cells that heavily infiltrate cancer cells, play a crucial role in tumor formation. Activated MCs can release histamine and a family of proteases through degranulation effects, concurrently achieving endothelial junction… read more here.
Keywords: tumor infiltrating; activation tumor; mast cells; tumor ... See more keywords
Abstract 3486: Click-to-release for controlled immune cell activation: tumor-targeted unmasking of an IL-12 prodrug in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3486
Abstract: Immunotherapy utilizing immune stimulating cytokines such as IL-12 holds great promise for the treatment of cancer. However, clinical use of IL-12 is hampered by severe toxicity following systemic administration resulting in a narrow therapeutic window.… read more here.
Keywords: tumor targeted; tumor; click release; activation tumor ... See more keywords