Extracellular vesicles from M1-polarized macrophages promote inflammation in the temporomandibular joint via miR-1246 activation of the Wnt/ β -catenin pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14590
Abstract: Macrophage-mediated regulation of chondrocytes plays an important role in promoting temporomandibular joint (TMJ) inflammation. We investigated whether extracellular vesicles (EVs) derived from M1 macrophages (M1-EVs) have a proinflammatory effect on TMJ inflammation and what the… read more here.
Keywords: extracellular vesicles; inflammation; temporomandibular joint; mir 1246 ... See more keywords
Activation of Wnt signaling in Axin2+ cells leads to osteodentin formation and cementum overgrowth.
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DOI: 10.1111/odi.14472
Abstract: OBJECTIVES In this study, we used the mouse incisor model to investigate the regulatory mechanisms of Wnt/β-catenin signaling on Axin2+ cells in tooth development. MATERIALS AND METHODS Axin2lacZ/+ reporter mice were used to define the… read more here.
Keywords: axin2 cells; signaling axin2; mouse; wnt signaling ... See more keywords
Abstract 880: Activation of the Wnt pathway is associated with GNASR201 mutant appendiceal cancer in the peritoneum
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DOI: 10.1158/1538-7445.am2023-880
Abstract: Background: Active mutations in the GNAS oncogene are frequent in appendiceal adenocarcinoma (AA) (~37%) and are also found less frequently in lung, colorectal, and endometrial cancers. Here, we performed differential gene expression analyses between GNASR201… read more here.
Keywords: appendiceal; wnt pathway; gnasr201c gnaswt; activation wnt ... See more keywords
Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway
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DOI: 10.1186/s13059-019-1685-4
Abstract: BackgroundCircular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate the function of a novel circRNA derived from the β-catenin gene locus, circβ-catenin.ResultsCircβ-catenin is… read more here.
Keywords: catenin; activation wnt; liver cancer; wnt pathway ... See more keywords
FOXC1 Negatively Regulates DKK1 Expression to Promote Gastric Cancer Cell Proliferation Through Activation of Wnt Signaling Pathway
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DOI: 10.3389/fcell.2021.662624
Abstract: Gastric cancer (GC), characterized by uncontrolled growth, is a common malignant tumor of the digestive system. The Wnt signaling pathway plays an important role in the tumorigenesis and proliferation of GC. Many studies on this… read more here.
Keywords: wnt signaling; proliferation; signaling pathway; expression ... See more keywords
Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
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DOI: 10.3390/biomedicines11041121
Abstract: Activation of microglia is one of the pathological bases of neuroinflammation, which involves various diseases of the central nervous system. Inhibiting the inflammatory activation of microglia is a therapeutic approach to neuroinflammation. In this study,… read more here.
Keywords: signaling pathway; wnt catenin; catenin signaling; activation wnt ... See more keywords
Association between Hepatic Oxidative Stress Related Factors and Activation of Wnt/β-Catenin Signaling in NAFLD-Induced Hepatocellular Carcinoma
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DOI: 10.3390/cancers14092066
Abstract: Simple Summary Activation of the Wnt/β-catenin signaling pathway may reduce the efficacy of immune checkpoint inhibitors, which are first-line therapeutic agents for the treatment of hepatocellular carcinoma (HCC). Following gadoxetate-enhanced MRI, HCC lesions may exhibit… read more here.
Keywords: serum ferritin; wnt catenin; activation wnt; catenin signaling ... See more keywords