Deep molecular response in patients with chronic phase chronic myeloid leukemia treated with the plasminogen activator inhibitor‐1 inhibitor TM5614 combined with a tyrosine kinase inhibitor
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DOI: 10.1002/cam4.5292
Abstract: We recently showed that pharmacological inhibition of plasminogen activator inhibitor‐1 (PAI‐1) activity, based on TM5614, increases cell motility and induces the detachment of hematopoietic stem cells from their niches. In this TM5614 phase II clinical… read more here.
Keywords: deep molecular; activator inhibitor; plasminogen activator; inhibitor ... See more keywords
Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cardiology"
DOI: 10.1002/clc.23282
Abstract: Association between plasminogen activator inhibitor‐1 (PAI‐1) rs1799889 polymorphism and venous thromboembolism (VTE) were explored by many previous studies, yet the findings of these studies were conflicting. read more here.
Keywords: activator inhibitor; rs1799889 polymorphism; venous thromboembolism; polymorphism venous ... See more keywords
Impact of scaling and root planing on salivary and serum Plasminogen Activator Inhibitor-1 expression in patients with periodontitis with and without type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontology"
DOI: 10.1002/jper.22-0129
Abstract: BACKGROUND Plasminogen Activator Inhibitor-1 (PAI-1) is significantly enhanced in insulin resistance and inflammation and ascribed as a pro-inflammatory marker. This study aimed to compare and correlate salivary and serum PAI-1 and alpha 2-macroglobulin (α2MG) in… read more here.
Keywords: salivary serum; serum; plasminogen activator; activator inhibitor ... See more keywords
Mathematical modelling of pattern formation in activator–inhibitor reaction–diffusion systems with anomalous diffusion
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Mathematical Chemistry"
DOI: 10.1007/s10910-019-01089-y
Abstract: Auto-wave solutions in nonlinear time-fractional reaction–diffusion systems are investigated. It is shown that stability of steady-state solutions and their subsequent evolution are mainly determined by the eigenvalue spectrum of a linearized system and level of… read more here.
Keywords: diffusion; activator inhibitor; anomalous diffusion; diffusion systems ... See more keywords
A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.12.005
Abstract: Plasminogen activator inhibitor-1 (PAI-1) is a labile molecule that exists in four different forms: active, latent, cleaved and target bound form. Although there have been many methods to measure the total PAI-1, the measurement of… read more here.
Keywords: activator inhibitor; pai; active form; novel elisa ... See more keywords
Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.08.029
Abstract: Abstract Background Tissue-type plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have been shown to be associated with increased risk for stroke, however, the association with incident atrial fibrillation (AF) is unknown. Methods We examined… read more here.
Keywords: plasminogen; activator inhibitor; prevend study; tissue ... See more keywords
The role of plasminogen activator inhibitor-1 in gynecological and obstetrical diseases: An update review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2022.103490
Abstract: In a normal pregnancy, maternal circulatory system presents a hypercoagulable state due to the effect of hormone secretion. Even minor variations in fibrinolytic system could lead to hyper- or hypofibrinolysis, affecting placental formation, and causing… read more here.
Keywords: pai; plasminogen activator; pregnancy; obstetrical diseases ... See more keywords
Role of plasminogen activator inhibitor-1 in oral tongue squamous cell carcinoma: An immunohistochemical and in vitro analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2021.104722
Abstract: OBJECTIVE To evaluate the influence of plasminogen activator inhibitor-1 (PAI-1) on the biological behavior and prognosis of oral tongue squamous cell carcinoma (OTSCC). METHODS Immunoexpression of PAI-1 was analyzed in 60 OTSCC specimens and classified… read more here.
Keywords: tongue squamous; oral tongue; activator inhibitor; expression ... See more keywords
Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients
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DOI: 10.1038/s41598-020-80010-z
Abstract: Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibrinolysis will help inform… read more here.
Keywords: hospitalized covid; covid patients; plasminogen; activator inhibitor ... See more keywords
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
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DOI: 10.1038/s42003-018-0255-8
Abstract: Mutations in SPINT2 encoding the epithelial serine protease inhibitor hepatocyte growth factor activator inhibitor-2 (HAI-2) are associated with congenital tufting enteropathy. However, the functions of HAI-2 in vivo are poorly understood. Here we used tamoxifen-induced… read more here.
Keywords: inhibitor; intestinal epithelium; factor activator; activator inhibitor ... See more keywords
P6450Plasminogen activator inhibitor type-1 (PAI-1) expression relates to the presence of myocardial inflammation in patients with nonischemic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.1043
Abstract: Plasminogen activator inhibitor type-1 (PAI-1) is an important inhibitor of the fibrinolytic pathway and an acute phase reactant in response to inflammatory cytokines, resulting in thrombosis, arteriosclerosis, and tissue fibrosis. It has been identified as… read more here.
Keywords: activator inhibitor; pai; inflammation; pai expression ... See more keywords