Development of an Orally Active Small-Molecule Inhibitor of Receptor Activator of Nuclear Factor-κB Ligand.
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DOI: 10.1021/acs.jmedchem.2c00081
Abstract: Receptor activator of nuclear factor-κB (RANK) and its ligand, RANKL, play pivotal roles in bone remodeling. The monoclonal antibody denosumab successfully inhibited the maturation of osteoclasts (OCs) by binding to RANKL in the clinic. We… read more here.
Keywords: nuclear factor; small molecule; receptor activator; activator nuclear ... See more keywords
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b02027
Abstract: Targeting RANKL/RANK offers the possibility of developing novel therapeutic approaches to treat bone metabolic diseases. Multiple efforts have been made to inhibit RANKL. For example, marketed monoclonal antibody drug Denosumab could inhibit the maturation of… read more here.
Keywords: receptor activator; activator nuclear; nuclear factor; rankl ... See more keywords
Commentary on the effects of receptor activator of nuclear factor‐B ligand inhibition on bone mass and muscle strength
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13165
Abstract: The pathophysiology of osteoporosis and sarcopenia. read more here.
Keywords: commentary effects; receptor activator; activator nuclear; factor ligand ... See more keywords
Differential expression of periostin, sclerostin, receptor activator of nuclear factor‐&kgr;B, and receptor activator of nuclear factor‐&kgr;B ligand genes in severe chronic periodontitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Investigative and Clinical Dentistry"
DOI: 10.1111/jicd.12369
Abstract: AIM The aim of the present study was to determine and compare the expression profile of periostin (POSTN), sclerostin (SOST), receptor activator nuclear factor-κB (RANK), and RANK ligand (RANKL) genes in gingival tissue samples collected… read more here.
Keywords: receptor activator; activator nuclear; expression; severe chronic ... See more keywords
Isofraxidin Inhibits Receptor Activator of Nuclear Factor-κB Ligand–Induced Osteoclastogenesis in Bone Marrow–Derived Macrophages Isolated from Sprague–Dawley Rats by Regulating NF-κB/NFATc1 and Akt/NFATc1 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Cell Transplantation"
DOI: 10.1177/0963689721990321
Abstract: Osteoporosis is a common bone disease that is characterized by decreased bone mass and fragility fractures. Isofraxidin is a hydroxy coumarin with several biological and pharmacological activities including an anti-osteoarthritis effect. However, the role of… read more here.
Keywords: receptor activator; activator nuclear; bone; factor ligand ... See more keywords
The Expression of Matrix Metalloproteinases in Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-expressing Cancer of Apocrine Origin.
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DOI: 10.21873/anticanres.12198
Abstract: Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive tumor entity. Since there is no conventional therapy for advanced PCAC, exploratory treatments are sometimes used. As we previously reported, receptor activator of nuclear… read more here.
Keywords: receptor activator; activator nuclear; ligand; apocrine ... See more keywords
Roles of osteoprotegerin in endocrine and metabolic disorders through receptor activator of nuclear factor kappa-B ligand/receptor activator of nuclear factor kappa-B signaling
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DOI: 10.3389/fcell.2022.1005681
Abstract: Endocrine and metabolic diseases show increasing incidence and high treatment costs worldwide. Due to the complexity of their etiology and mechanism, therapeutic strategies are still lacking. Osteoprotegerin (OPG), a member of the tumor necrosis factor… read more here.
Keywords: nuclear factor; receptor activator; activator nuclear; factor ... See more keywords
Receptor activator of nuclear factor-κB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1043975
Abstract: Osteoclast is a hematopoietic precursor cell derived from the mononuclear macrophage cell line, which is the only cell with bone resorption function. Its abnormal activation can cause serious osteolysis related diseases such as rheumatoid arthritis,… read more here.
Keywords: nuclear factor; receptor activator; activator nuclear; natural compounds ... See more keywords
Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers
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DOI: 10.3390/ijms23031742
Abstract: The receptor activator of nuclear factor kappa B (RANK) is becoming recognized as a master regulator of tumorigenesis, yet its role in gynecological cancers remains mostly unexplored. We investigated whether there is a gradation of… read more here.
Keywords: rank; receptor activator; tumor; expression ... See more keywords
Lophatherum gracile Bronghiart Suppresses Receptor Activator of Nuclear Factor Kappa-B Ligand-Stimulated Osteoclastogenesis and Prevents Ovariectomy-Induced Osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213942
Abstract: Lophatherum gracile Bronghiart, used in traditional herbal medicine, has many biological properties including antiviral, antipyretic, antitumor, vasorelaxation, and neutrophilic inflammatory effects. However, its modulatory effects on bone metabolism have not been investigated previously. In this… read more here.
Keywords: nuclear factor; gracile bronghiart; lophatherum gracile; receptor activator ... See more keywords
CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation.
Sign Up to like & getrecommendations! Published in 2020 at "World journal of stem cells"
DOI: 10.4252/wjsc.v12.i3.222
Abstract: BACKGROUND Radiation induces rapid bone loss and enhances bone resorption and adipogenesis, leading to an increased risk of bone fracture. There is still a lack of effective preventive or therapeutic method for irradiation-induced bone injury.… read more here.
Keywords: receptor activator; activator nuclear; crif1; factor ... See more keywords