Inexpensive protein overexpression driven by the NarL transcription activator protein
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28071
Abstract: Most Escherichia coli overexpression vectors used for recombinant protein production (RPP) depend on organic inducers, for example, sugars or simple conjugates. However, these can be expensive and, sometimes, chemically unstable. To simplify this and to… read more here.
Keywords: transcription activator; overexpression; activator protein; narl transcription ... See more keywords
OLFML2A is necessary for anti-triple negative breast cancer effect of selective activator protein‐1 inhibitor T-5224
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101100
Abstract: Highlights • Expression of activator protein-1 (AP-1) family is significantly elevated in triple-negative breast cancer (TNBC), compared with that in other breast cancer subtypes.• T-5224, an inhibitor of c-Fos/AP-1 resulted in increase of apoptosis and… read more here.
Keywords: negative breast; breast; breast cancer; activator protein ... See more keywords
VEGFR‐3 signaling is regulated by a G‐protein activator, activator of G‐protein signaling 8, in lymphatic endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.007
Abstract: ABSTRACT Vascular endothelial growth factor C (VEGFC) and its cognate receptor VEGFR‐3 play a key role in lymphangiogenesis. We previously reported that an ischemia‐inducible G&bgr;&ggr; signal regulator, activator of G‐protein signaling 8 (AGS8), regulated the… read more here.
Keywords: activator; protein signaling; endothelial cells; lymphatic endothelial ... See more keywords
Discovery of the ATPase Activity of a Cobalt-Type Nitrile Hydratase Activator and Its Promoting Effect on Enzyme Maturation.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00167
Abstract: An activator protein and a metal ion are two factors known to be indispensable for the maturation of nitrile hydratase (NHase). Here, the third key factor, adenosine triphosphate (ATP), was identified to play an important… read more here.
Keywords: activator protein; atpase activity; activity; nitrile hydratase ... See more keywords
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx509
Abstract: Abstract The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes.… read more here.
Keywords: protein; inflammatory genes; dna binding; binds directly ... See more keywords
Roles of activator protein-2 gamma in breast cancer: A narrative review (SANRA)
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030587
Abstract: Activator protein-2 gamma (AP-2γ) is a crucial transcription factor involved in breast cancer development. Abnormal expression and activity of AP-2γ have also been identified as important markers of malignancy. In the last decade, the importance… read more here.
Keywords: review; breast; activator protein; breast cancer ... See more keywords
RNA editing‐mediated regulation of calcium‐dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15372
Abstract: Calcium‐dependent activator protein for secretion 1 (CAPS1) is a SNARE accessory protein that facilitates formation of the SNARE complex to enable neurotransmitter release. Messenger RNAs encoding CAPS1 are subject to a site‐specific adenosine‐to‐inosine (A‐to‐I) editing… read more here.
Keywords: protein; calcium dependent; dependent activator; localization ... See more keywords
Abstract 3532: Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3532
Abstract: Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and is required for DNA replication and the repair of DNA damage. Multiple types of cancer, including Ewing sarcoma tumors, are… read more here.
Keywords: sarcoma; ewing sarcoma; activator protein; sarcoma cells ... See more keywords
Intersection of two key signal integrators in the cell: activator of G protein Signaling 3 and Dishevelled-2.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.247908
Abstract: Activator of G protein Signaling 3 (AGS3) was discovered as a one of several receptor independent activators of G protein signaling, which are postulated to provide a platform of divergence between canonical and noncanonical G… read more here.
Keywords: protein; ags3 dvl2; protein signaling; cell ... See more keywords
Two patients from Turkey with a novel variant in the GM2A gene and review of the literature
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2020-0655
Abstract: Abstract Objectives GM2 gangliosidosis is a rare form of inborn errors of metabolism including Tay-Sachs disease, Sandhoff disease, and GM2 activator deficiency. GM2 activator protein deficiency is an ultra-rare form of GM2 gangliosidosis. To date,… read more here.
Keywords: protein deficiency; gm2 activator; activator; activator protein ... See more keywords