Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24328
Abstract: Diabetes patients with painful diabetic neuropathy (PDN) show severe spinal atrophy, suggesting pathological changes of the spinal cord contributes to central sensitization. However, the cellular changes and underlying molecular mechanisms within the diabetic spinal cord… read more here.
Keywords: diabetic neuropathy; spinal astrocytes; signal transducer; painful diabetic ... See more keywords
Signal transducer and activator of transcription family is a prognostic marker associated with immune infiltration in endometrial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24315
Abstract: Signal transducer and activator of transcription (STAT) is a unique protein family that binds to DNA and plays a vital role in regulating major physiological cellular processes. Seven STAT genes have been identified in the… read more here.
Keywords: family; signal transducer; infiltration endometrial; activator transcription ... See more keywords
Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.12.008
Abstract: T-helper 17 (Th17) cells are involved in the occurrence and development of several inflammation-associated diseases. Interleukin (IL)-17, the main cytokine secreted by differentiated Th17 cells, mediates immunoreactions and plays important roles in immunological diseases, including… read more here.
Keywords: signal transducer; activator transcription; transducer activator; th17 cells ... See more keywords
Signal transducer and activator of transcription 3 as a potential therapeutic target for Graves’ orbitopathy
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111363
Abstract: The roles of signal transducer and activator of transcription 3 (STAT3) in inflammation, oxidative stress, and adipogenesis during Graves' orbitopathy (GO) are incompletely understood. Here, STAT3 expression in orbital tissues (from individuals with GO and… read more here.
Keywords: activator transcription; transducer activator; signal transducer; graves orbitopathy ... See more keywords
Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Animal Science"
DOI: 10.1093/jas/skac118
Abstract: Abstract Heat stress (HS) compromises almost every aspect of animal agriculture including reproduction. In pigs, this infecundity is referred to as seasonal infertility (SI), a phenotype including ovarian dysfunction. In multiple species, HS-induced hyperprolactinemia has… read more here.
Keywords: signal transducer; transducer activator; activator transcription;
Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient.
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Infectious Disease Journal"
DOI: 10.1097/inf.0000000000002090
Abstract: A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics… read more here.
Keywords: transcription deficient; activator transcription; signal transducer; deficient patient ... See more keywords
Dermokine contributes to epithelial–mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer
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DOI: 10.1111/cas.13347
Abstract: Dermokine (DMKN) was first identified in relation to skin lesion healing and skin carcinoma. Recently, its expression was associated with pancreatic cancer tumorigenesis, although its involvement remains poorly understood. Herein, we showed that DMKN loss… read more here.
Keywords: signal transducer; activator transcription; transducer activator; pancreatic cancer ... See more keywords
Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue: an important histological marker for diagnosis of primary Sjögren’s syndrome
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DOI: 10.1136/rmdopen-2022-002694
Abstract: Objectives The pathological diagnostic criteria for primary Sjögren’s syndrome (SjS) have certain limitations. We first explored the key pathogenic pathways of SjS through a bioinformatics approach, and then evaluated the diagnostic value of the important… read more here.
Keywords: primary gren; gren syndrome; phosphorylated signal; signal transducer ... See more keywords
The relationship between microRNAs and the STAT3-related signaling pathway in cancer
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DOI: 10.1177/1010428317719869
Abstract: MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3′ untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to carcinogenesis,… read more here.
Keywords: activator transcription; transducer activator; transcription; signal transducer ... See more keywords
Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.708325
Abstract: Chronic Chagasic cardiomyopathy (CCC) is a severe clinical manifestation that develops in 30%–40% of individuals chronically infected with the protozoal parasite Trypanosoma cruzi and is thus an important public health problem. Parasite persistence during chronic… read more here.
Keywords: signal transducer; chagasic cardiomyopathy; chronic chagasic; activator transcription ... See more keywords
Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00168
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells… read more here.
Keywords: activator transcription; transducer activator; transcription; signal transducer ... See more keywords