Characterization of CFTR Activators and Inhibitors by the use of a Planar Patch Clamp System
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DOI: 10.1016/j.bpj.2016.11.2561
Abstract: Cystic fibrosis is caused by malfunction of the chloride channel Cystic Fibrosis Transmembrane Regulator (CFTR). CFTR is expressed in the apical membrane of epithelial cells where it is involved in the regulation of fluid transport… read more here.
Keywords: activators inhibitors; cftr; characterization cftr; forskolin ... See more keywords
Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors
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DOI: 10.1021/acs.jcim.1c00439
Abstract: Opioid receptors (OPRs) are the main targets for the treatment of pain and related disorders. The opiate compounds that activate these receptors are effective analgesics but their use leads to adverse effects, and they often… read more here.
Keywords: activators inhibitors; small molecule; predictive models; opioid receptors ... See more keywords
Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit.
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DOI: 10.1021/acschembio.8b00610
Abstract: The increasing rate of resistance development to conventional antibiotics by bacteria necessitates the identification of alternative treatment possibilities that can reduce the ability of bacteria to adapt. Enterococcus faecalis remains the leading cause of clinical… read more here.
Keywords: potent activators; activators inhibitors; quorum sensing; enterococcus faecalis ... See more keywords
Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors
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DOI: 10.3390/polym14102021
Abstract: To expand the range of daphnetin-based inhibitors/activators used for targeting G protein-coupled receptors (GPCRs) in disease treatment, twenty-five coumarin derivatives 1–25, including 7,8-dihydroxycoumarin and 7-hydroxycoumarin derivatives with various substitution patterns/groups at C3-/4- positions, were synthesized… read more here.
Keywords: coumarin derivatives; protein coupled; synthesis coumarin; activators inhibitors ... See more keywords