Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras.
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DOI: 10.2174/1381612829666230418114520
Abstract: The most frequent mutated oncogene KRAS in lung cancer is targeted by KRAS G12C-directed drugs, such as Sotorasib and Adagrasib. Still, other alleles frequently expressed in pancreatic and colon cancer may be attacked indirectly by… read more here.
Keywords: sos1 activators; targeting sos1; sos1; activators proteolysis ... See more keywords