Interleukin-23 drives expansion of Thelper 17 cells through epigenetic regulation by signal transducer and activators of transcription 3 in lupus patients.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa176
Abstract: OBJECTIVES To elucidate the molecular mechanisms underlying pathogenic Th17 cells, we investigated the modulation of epigenetic modifications and its association with SLE. METHODS Naive CD4+ T cells were cultured in Th17 polarizing conditions for 5 days… read more here.
Keywords: expansion; th17 cells; activators transcription; th17 cell ... See more keywords
Janus kinase-signal transducers and activators of transcription cell signaling in Spondyloarthritis: rationale and evidence for JAK inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in rheumatology"
DOI: 10.1097/bor.0000000000000810
Abstract: PURPOSE OF REVIEW The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling proteins represent a group of intracellular kinase molecules that play a central role in the signaling pathways induced by cytokines, chemokines, and… read more here.
Keywords: signal transducers; activators transcription; janus kinase; kinase signal ... See more keywords
Tofacitinib Represses the Janus Kinase-Signal Transducer and Activators of Transcription Signalling Pathway in Keratinocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Acta dermato-venereologica"
DOI: 10.2340/00015555-2960
Abstract: Tofacitinib is a Janus kinase (JAK) inhibitor, which has shown efficacy in treating psoriasis. The mode of action of tofacitinib is not completely understood but it has been thought to be mediated by the inhibition… read more here.
Keywords: tofacitinib; signal transducer; activators transcription; transducer activators ... See more keywords
Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15070835
Abstract: The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information… read more here.
Keywords: activators transcription; transducers activators; signal transducers; transcription stat3 ... See more keywords