The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1101/2022.07.27.500934
Abstract: While the biochemistry of gene transcription has been well studied, our understanding of how this process is organised in 3D within the intact nucleus is less well understood. Here we investigate the structure of actively… read more here.
Keywords: active chromatin; rna polymerase; microscopy; super resolution ... See more keywords
Condensed but liquid-like domain organization of active chromatin regions in living human cells
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf1488
Abstract: In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as domains, for various cellular functions. However, their physical nature in living cells remains unclear (e.g., condensed domains or extended fiber loops; liquid-like or solid-like). Using novel… read more here.
Keywords: liquid like; active chromatin; human cells; chromatin ... See more keywords