Simple Liquid Chromatography-Tandem Mass Spectrometry Method for Quantitation of Total and Free Aprepitant and its Active N-Dealkylated Metabolites in Human Plasma.
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DOI: 10.1097/ftd.0000000000000815
Abstract: BACKGROUND Aprepitant, an antiemetic selective neurokinin-1 receptor antagonist, is primarily metabolized to the active N-dealkylated (ND-AP) form and then converted to its carbonyl (ND-CAP) form in humans. This study developed simple liquid chromatography-tandem mass spectrometry… read more here.
Keywords: dealkylated metabolites; active dealkylated; aprepitant; total free ... See more keywords