Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113555
Abstract: Quinoline is one of the most important and versatile nitrogen heterocycles embodied in several biologically active molecules. Within the numerous quinolines developed as antiproliferative agents, this review is focused on compounds interfering with DNA structure… read more here.
Keywords: quinoline anticancer; active dna; anticancer agents; dna ... See more keywords
MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2016.12.020
Abstract: Somatic cell reprogramming by transcription factors and other modifiers such as microRNAs has opened broad avenues for the study of developmental processes, cell fate determination, and interplay of molecular mechanisms in signaling pathways. However, many… read more here.
Keywords: wnt signaling; active dna; mir; microrna impairs ... See more keywords
The plasticity of redox cofactors: from metalloenzymes to redox-active DNA
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Chemistry"
DOI: 10.1038/s41570-018-0029-3
Abstract: Metal cofactors considerably widen the catalytic space of naturally occurring enzymes whose specific and enantioselective catalytic activity constitutes a blueprint for economically relevant chemical syntheses. To optimize natural enzymes and uncover novel reactivity, we need… read more here.
Keywords: active dna; redox cofactors; redox active; cofactors metalloenzymes ... See more keywords
Photochemically active DNA-intercalating ruthenium and related complexes – insights by combining crystallography and transient spectroscopy
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc01070b
Abstract: Recent research on the study of the interaction of ruthenium polypyridyl compounds and defined sequence nucleic acids is reviewed. read more here.
Keywords: ruthenium; dna intercalating; active dna; photochemically active ... See more keywords
A novel protein complex that regulates active DNA demethylation in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13045
Abstract: Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene expression. The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base excision repair pathway for active DNA demethylation and is required for the prevention… read more here.
Keywords: protein; active dna; dna; genomic regions ... See more keywords
Active DNA demethylation promotes cell fate specification and the DNA damage response
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add9838
Abstract: Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification—induced pluripotent stem cell–derived neurons… read more here.
Keywords: active dna; dna demethylation; dna; dna damage ... See more keywords
Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance of Active DNA Methylation Changes in Rat Sperm
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00207
Abstract: DNA methylation is the major focus of studies on paternal epigenetic inheritance in mammals, but most previous studies about inheritable DNA methylation changes are passively induced by environmental factors. However, it is unclear whether the… read more here.
Keywords: methylation; active dna; rat sperm; methylation changes ... See more keywords