Active Efflux Leads to Heterogeneous Dissipation of Proton Motive Force by Protonophores in Bacteria
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DOI: 10.1128/mbio.00676-21
Abstract: Various toxic compounds disrupt bacterial physiology. While bacteria harbor defense mechanisms to mitigate the toxicity, these mechanisms are often coupled to the physiological state of the cells and become ineffective when the physiology is severely… read more here.
Keywords: proton motive; motive force; active efflux; force ... See more keywords
Nose-to-Brain Delivery of Antiviral Drugs: A Way to Overcome Their Active Efflux?
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DOI: 10.3390/pharmaceutics10020039
Abstract: Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters,… read more here.
Keywords: nose brain; antiviral drugs; active efflux; delivery antiviral ... See more keywords