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   Articles with "active esters" as a keyword



Utilizing N‐Hydroxylamine‐Based Active Esters for the Synthesis of Oseltamivir Amide Derivatives

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recommendations! Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202401139

Abstract: Functionalizing and derivatizing pharmaceuticals are essential for preparing new potentially active compounds. This work shows how active esters derived from oseltamivir carboxylate can be useful synthetic tools for accessing various amide derivatives of oseltamivir. Six… read more here.

Keywords: utilizing hydroxylamine; based active; amide derivatives; hydroxylamine based ... See more keywords
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Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis.

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recommendations! Published in 2020 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.0c03125

Abstract: We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters using an Ir photocatalyst under visible light irradiation. The method provides access to a broad range of aliphatic fluorides, including primary, secondary, and tertiary… read more here.

Keywords: fluorination redox; active esters; nucleophilic radio; fluorination ... See more keywords

Diastereoselective addition of redox active esters to azomethine imines by electrosynthesis.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc01795d

Abstract: Thanks to metal- and catalyst-free electrochemical conditions in an undivided cell, a series of readily available redox-active N-(acyloxy)phthalimide esters led to an efficient and highly stereoselective addition (85 : 15 to 95 : 5 dr) of putative radical species… read more here.

Keywords: diastereoselective addition; azomethine imines; redox active; addition redox ... See more keywords

α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes

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recommendations! Published in 2022 at "Chemical Science"

DOI: 10.1039/d2sc00500j

Abstract: α-Branched amines are fundamental building blocks in a variety of natural products and pharmaceuticals. Herein is reported a unique cascade reaction that enables the preparation of α-branched amines bearing aryl or alkyl groups at the… read more here.

Keywords: branched amines; amines radical; redox active; active esters ... See more keywords

Enantioselective Reactions of Redox-Active Esters Catalyzed via Cooperative Photoredox/Chiral Phosphoric Acid Catalysis

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recommendations! Published in 2025 at "Synthesis"

DOI: 10.1055/a-2675-3733

Abstract: Redox-active esters have garnered significant interest owing to their bench stability and photochemical reactivity. When combined with photoredox and chiral phosphoric acid catalysis, these esters enable the formation of new carbon–carbon bonds while concurrently inducing… read more here.

Keywords: photoredox chiral; chiral phosphoric; acid catalysis; redox active ... See more keywords