Widespread adenine N6-methylation of active genes in fungi
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3859
Abstract: N6-methyldeoxyadenine (6mA) is a noncanonical DNA base modification present at low levels in plant and animal genomes, but its prevalence and association with genome function in other eukaryotic lineages remains poorly understood. Here we report… read more here.
Keywords: adenine methylation; genes fungi; methylation active; widespread adenine ... See more keywords
Loss of Polycomb proteins CLF and LHP1 leads to excessive RNA degradation in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac216
Abstract: Polycomb-group (PcG) proteins are major chromatin complexes that regulate gene expression, mainly described as repressors keeping genes in a transcriptional silent state during development. Recent studies have nonetheless suggested that PcG proteins might have additional… read more here.
Keywords: polycomb; active genes; rna degradation; pcg proteins ... See more keywords
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad180
Abstract: Abstract The Paf1 complex (Paf1C) is a conserved transcription elongation factor that regulates transcription elongation efficiency, facilitates co-transcriptional histone modifications, and impacts molecular processes linked to RNA synthesis, such as polyA site selection. Coupling of… read more here.
Keywords: active genes; elongation; genes saccharomyces; paf1 complex ... See more keywords
Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.884707
Abstract: The advent of open access to genomic data offers new opportunities to revisit old clinical debates while approaching them from a different angle. We examine anew the question of whether psychiatric and neurological disorders are… read more here.
Keywords: topology; psychiatric neurological; active genes; neurological disorders ... See more keywords