Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling
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DOI: 10.1038/onc.2016.407
Abstract: Pancreatic ductal adenocarcinoma (PDAC) cells usually overexpress the epidermal growth factor receptor (EGFR); however, most are resistant to the anti-EGFR monoclonal antibody, cetuximab. In this study, we report that the molecular mechanism of resistance to… read more here.
Keywords: src akt; integrin driven; pdac cells; active integrin ... See more keywords
GGA2 and RAB13 promote activity-dependent β1-integrin recycling
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DOI: 10.1242/jcs.233387
Abstract: ABSTRACT β1-integrins mediate cell–matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here, we employ an RNAi screen to characterize regulators of… read more here.
Keywords: gga2 rab13; active integrin; integrin; integrin recycling ... See more keywords
The βI domain promotes active β1 integrin clustering into mature adhesion sites
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DOI: 10.26508/lsa.202201388
Abstract: Mana et al show that the extracellular headpiece βI domain is involved in conformationally active β1 integrin clustering, fibrillar adhesion formation, incorporation of soluble fibronectin dimers into fibrillar polymers, and extracellular matrix–dependent endothelial cell migration.… read more here.
Keywords: adhesion; domain promotes; integrin clustering; domain ... See more keywords