Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.
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DOI: 10.1093/intimm/dxaa073
Abstract: MDA5 is a cytoplasmic sensor of viral RNA, triggering type-I interferon (IFN-I) production. Constitutively active MDA5 has been linked to autoimmune diseases such as systemic lupus erythematosus, Singleton-Merten syndrome (SMS), and Aicardi-Goutières syndrome (AGS), a… read more here.
Keywords: aicardi gouti; constitutively active; encephalitis; active mda5 ... See more keywords