Effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its active metabolites
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2522-5
Abstract: PurposeCYP3A4, CYP2C19, and CYP3A5 are primarily involved in the metabolism of cilostazol. We investigated the effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its two active metabolites.MethodsThirty-three healthy Korean volunteers… read more here.
Keywords: polymorphisms pharmacokinetics; cyp2c19 cyp3a5; active metabolites; cyp3a5 genetic ... See more keywords
Active Metabolites from the Fungus Pestalotiopsis sp. YMF1.0474
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DOI: 10.1007/s10600-021-03331-z
Abstract: The chemical constituents of the fungus Pestalotiopsis sp. YMF1.0474 were studied. Five compounds, including a new pestalrone C (1) and four known compounds, namely, 6-[1-hydroxy-(1S)-pentyl]-4-methoxy-(6S)-2H,5H-pyran-2-one (2), LL-P880β (3), pestalrone A (4), and methyl (E)-octadec-9-enoate (5),… read more here.
Keywords: pestalotiopsis ymf1; ymf1 0474; fungus pestalotiopsis; ymf1 ... See more keywords
Role of gut microbiota in identification of novel TCM-derived active metabolites
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DOI: 10.1007/s13238-020-00784-w
Abstract: Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying… read more here.
Keywords: active metabolites; tcm; microbiota identification; gut microbiota ... See more keywords
Method development and validation for simultaneous determination of six tyrosine kinase inhibitors and two active metabolites in human plasma/serum using UPLC-MS/MS for therapeutic drug monitoring.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114562
Abstract: Over the past decades, therapeutic drug monitoring (TDM) of tyrosine kinase inhibitors (TKIs) and their main active metabolites has shown benefits in improving treatment efficacy and safety. Therefore, a sensitive, simple and economical ultrahigh-performance liquid… read more here.
Keywords: therapeutic drug; drug monitoring; active metabolites; plasma serum ... See more keywords
The adenylate cyclase activator forskolin potentiates the positive inotropic effect of the phosphodiesterase inhibitor milrinone but not of the calcium sensitizer levosimendan nor of its hemodynamically active metabolites: an apparent conundrum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001235
Abstract: ABSTRACT OR-1855 and OR-1896 are two hemodynamically active metabolites of the inodilator levosimendan, with calcium sensitizing activity, but their mechanism of action is still not fully understood.It has been previously reported that the positive inotropic… read more here.
Keywords: inotropic effect; positive inotropic; forskolin; active metabolites ... See more keywords
Clinical Validation of a Dried Blood Spot Assay for 8 Antihypertensive Drugs and 4 Active Metabolites.
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DOI: 10.1097/ftd.0000000000000703
Abstract: BACKGROUND Drug non-adherence is one of the major challenges faced by resistant hypertension patients, and identification of this problem is needed for optimizing pharmacotherapy. Dried blood spot (DBS) sampling is a minimally invasive method designed… read more here.
Keywords: clinical validation; blood spot; antihypertensive drugs; validation ... See more keywords
Development and Validation of a Dried Blood Spot Assay Using UHPLC-MS/MS to Identify and Quantify 12 Antihypertensive Drugs and 4 Active Metabolites: Clinical Needs and Analytical Limitations
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000984
Abstract: Supplemental Digital Content is Available in the Text. Purpose: As nonadherence to antihypertensive drugs (AHDs) can increase the risk of cardiovascular events, hospitalization, and higher costs, there is a need for a reliable, objective, and… read more here.
Keywords: validation; blood spot; active metabolites; dried blood ... See more keywords
Simultaneous Determination of Rifamycin Antibiotics and Their Active Metabolites in Human Plasma Using UHPLC-MS/MS to Evaluate Their Impact on Target Peak Concentrations: A Short Communication.
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DOI: 10.1097/ftd.0000000000001098
Abstract: BACKGROUND Standard and proper antituberculosis (anti-TB) treatment is essential for patients with TB, and rifamycin antibiotics are key components of anti-TB therapy. Therapeutic drug monitoring (TDM) of rifamycin antibiotics can shorten the time to response… read more here.
Keywords: rifamycin antibiotics; antibiotics active; active metabolites; determination rifamycin ... See more keywords
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
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DOI: 10.1124/dmd.116.074815
Abstract: Glyburide is widely used for the treatment of type 2 diabetes. We studied the mechanisms involved in the disposition of glyburide and its pharmacologically active hydroxy metabolites M1 and M2b and evaluated their clinical pharmacokinetics… read more here.
Keywords: clinical pharmacokinetics; disposition; transporter mediated; active metabolites ... See more keywords
Stereoselective Metabolism of Bupropion to Active Metabolites in Cellular Fractions of Human Liver and Intestine
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DOI: 10.1124/dmd.122.000867
Abstract: Striking stereoselective disposition of the antidepressant and smoking cessation aid bupropion (BUP) and its active metabolites observed clinically influence patients’ response to BUP therapy and its clinically important drug-drug interactions (DDI) with CYP2D6 substrates. However,… read more here.
Keywords: metabolism; cellular fractions; active metabolites; stereoselective metabolism ... See more keywords
Profiling of Biologically Active Metabolites of Spergula fallax L. Using High-Resolution UPLC-QTOF- MS.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201023666220209125306
Abstract: BACKGROUND Medicinal plants are recognized to have a wide range of important biological activities, Spergula fallax L. is a well-known plant while phytochemical and biological activities screening of the species are rare. OBJECTIVE This study… read more here.
Keywords: high resolution; active metabolites; spergula fallax; activity ... See more keywords