Lipophilicity assessment of some isoniazid derivatives active against Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.124820
Abstract: Abstract Micelle-water partition coefficients, log Kp(NaDS/w), and octanol-water partition coefficients, log Po/w, for 9 isoniazid derivatives, previously assessed as active against Mycobacterium tuberculosis, were determined using derivative spectrophotometry and the shake flask method in buffer… read more here.
Keywords: lipophilicity; mycobacterium tuberculosis; active mycobacterium; isoniazid derivatives ... See more keywords
Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01237-22
Abstract: The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. ABSTRACT The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium… read more here.
Keywords: opc 167832; dpre1; mycobacterium abscessus; mycobacterium ... See more keywords