Holistic analytical characterization and risk assessment of residual host cell protein impurities in an active pharmaceutical ingredient synthesized by biocatalysts
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28112
Abstract: Host cell proteins (HCPs) are a significant class of process‐related impurities commonly associated with the manufacturing of biopharmaceuticals. However, due to the increased use of crude enzymes as biocatalysts for modern organic synthesis, HCPs can… read more here.
Keywords: cell; active pharmaceutical; risk assessment; host cell ... See more keywords
Active Pharmaceutical Ingredient Uptake by Zebrafish (Danio rerio) Oct2 (slc22a2) Transporter Expressed in Xenopus laevis Oocytes
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5480
Abstract: Uptake of active pharmaceutical ingredients (APIs) across the gill epithelium of fish is via either a passive or facilitated transport process, with the latter being more important at the lower concentrations more readily observed in… read more here.
Keywords: oct2 slc22a2; toxicology; chemistry; transporter ... See more keywords
ToF‐SIMS depth profiling of oral drug delivery films for 3D visualization of active pharmaceutical particles
Sign Up to like & getrecommendations! Published in 2019 at "Surface and Interface Analysis"
DOI: 10.1002/sia.6707
Abstract: The size, shape, and spatial distribution of active pharmaceutical ingredient (API) are important physical characteristics of drug delivery systems that can affect the performance, stability, appearance, and even bulk properties of the end product. This… read more here.
Keywords: active pharmaceutical; delivery films; tof sims; drug delivery ... See more keywords
Interaction Between an Active Pharmaceutical Ingredient Ionic Liquid Benzalkonium Salicylate and Small Biomolecules in Aqueous Solution: UV Absorption, Conductivity, and Volumetric Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-018-0810-4
Abstract: UV absorption spectroscopy, electrical conductivity and density experiments have been used to investigate the interactions of some small biomolecules (amino acids/dipeptides) with an active pharmaceutical ingredient in ionic liquid form (API-IL), benzalkonium salicylate (BaSal), in… read more here.
Keywords: ingredient ionic; small biomolecules; active pharmaceutical; pharmaceutical ingredient ... See more keywords
Fate of active pharmaceutical ingredients in a northern high-rate algal pond fed with municipal wastewater.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.129763
Abstract: Active pharmaceutical ingredients (APIs) are vital to human health and welfare, but following therapeutic use, they may pose a potential ecological risk if discharged into the environment. Today's conventional municipal wastewater treatment plants are not… read more here.
Keywords: active pharmaceutical; wastewater; high rate; municipal wastewater ... See more keywords
Tailoring the crystal size distribution of an active pharmaceutical ingredient by continuous antisolvent crystallization in a planar oscillatory flow crystallizer
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Research and Design"
DOI: 10.1016/j.cherd.2021.08.030
Abstract: Abstract An active pharmaceutical ingredient is currently produced in a traditional batch antisolvent crystallization process. Although well-established, this process lacks flexibility to control the crystal size distribution (CSD). Therefore, a new process was developed to… read more here.
Keywords: planar; antisolvent crystallization; crystal size; pharmaceutical ingredient ... See more keywords
Equivalence in Active Pharmaceutical Ingredient of Generic Antihypertensive Medicines Available in Nigeria (EQUIMEDS): A Case for Further Surveillance.
Sign Up to like & getrecommendations! Published in 2019 at "Global heart"
DOI: 10.1016/j.gheart.2019.07.006
Abstract: BACKGROUND Widespread access to good quality antihypertensive medicines is a critical component for reducing premature cardiovascular disease (CVD) mortality. Poor-quality medicines pose serious health concerns; however, there remains a knowledge gap about the quality of… read more here.
Keywords: medicine; quality; generic antihypertensive; antihypertensive medicines ... See more keywords
Application of hydrophilic interaction liquid chromatography for the quantification of succinylcholine in Active Pharmaceutical Ingredient and medicinal product. Identification of new impurities of succinylcholine chloride
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e01097
Abstract: A new method, using hydrophilic interaction chromatography (HILIC), for quantification of succinylcholine and impurities in Active Pharmaceutical Ingredient (API), as well as in the medicinal product, was developed. Additionally, the new impurities in API were… read more here.
Keywords: chromatography; new impurities; active pharmaceutical; hydrophilic interaction ... See more keywords
Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug loading via dry particle coating
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.002
Abstract: &NA; It has been shown that dry coating cohesive active pharmaceutical ingredients (APIs) with nano‐silica can improve packing and flow of their blends, facilitating high speed direct compression tableting. This paper examines the broader scope… read more here.
Keywords: drug loading; active pharmaceutical; nano silica; particle ... See more keywords
The influence of polymeric excipients on desupersaturation profiles of active pharmaceutical ingredients. 1: Polyethylene glycol.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119317
Abstract: Polymeric excipients have proven to be beneficial in stabilizing supersaturated solutions of poorly soluble active pharmaceutical ingredients (APIs). They are therefore considered an important tool in improving oral bioavailability of such APIs. To better understand… read more here.
Keywords: crystal growth; active pharmaceutical; polymeric excipients; desupersaturation ... See more keywords
Polymorphism of benzylthiouracil, an active pharmaceutical ingredient against hyperthyroidism.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120378
Abstract: The crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates of the two independent molecules of form I have been obtained for the first time. The dimorphism convincingly… read more here.
Keywords: hyperthyroidism; ingredient hyperthyroidism; benzylthiouracil active; active pharmaceutical ... See more keywords