Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants.
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DOI: 10.1021/jacs.3c09694
Abstract: Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis and bone development, and aberrant PTH1R activity underlies several human diseases. Peptidic PTH1R antagonists and inverse agonists have therapeutic potential in treating… read more here.
Keywords: active pth1r; constitutively active; pth1r; backbone modification ... See more keywords