Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_461
Abstract: The structure of the human kappa opioid receptor (KOR) in complex with the long-acting antagonist JDTic was solved crystallographically in 2012 and, along with structures of other opioid receptors, revolutionized our understanding of opioid system… read more here.
Keywords: kor inactive; characterization kor; pharmacology; active states ... See more keywords
Differentiating between Inactive and Active States of Rhodopsin by Atomic Force Microscopy in Native Membranes.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00546
Abstract: Membrane proteins, including G protein-coupled receptors (GPCRs), present a challenge in studying their structural properties under physiological conditions. Moreover, to better understand the activity of proteins requires examination of single molecule behaviors rather than ensemble… read more here.
Keywords: state; microscopy; active states; inactive active ... See more keywords