Synthesis of Optically Active syn- and anti-Chlorohydrins through a Bienzymatic Reductive Cascade
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DOI: 10.1021/acs.orglett.2c02592
Abstract: A bienzymatic cascade has been designed and optimized to obtain enantiopure chlorohydrins starting from the corresponding 1-aryl-2-chlorobut-2-en-1-ones. For the synthesis of these α-chloroenones, a two-step sequence was developed consisting of the allylation of the corresponding… read more here.
Keywords: cascade; active syn; optically active; anti chlorohydrins ... See more keywords