Overcoming the On‐Target Toxicity in Antibody‐Mediated Therapies via an Indirect Active Targeting Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206912
Abstract: Antibody‐based therapies could be led astray when target receptors are expressed on nontarget sites, and the on‐target toxicity poses critical challenges to clinical applications. Here, a biomimetic indirect active targeting (INTACT) strategy is proposed based… read more here.
Keywords: active targeting; strategy; target toxicity; indirect active ... See more keywords
Synthetic peptide-labelled micelles for active targeting of cells overexpressing EGF receptors
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02755-w
Abstract: The goal of nanomedicine is to transport drugs to pathological tissues, reducing side effects while increasing targeting and efficacy. Aggregates grafted by bioactive molecules act as the active targeting agents. Among bioactive molecules, peptides, which… read more here.
Keywords: active targeting; peptide; peptide labelled; cells overexpressing ... See more keywords
Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.05.030
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating malignancies in patients, and there is an urgent need for an effective treatment method. Herein, we report a novel gold nanocluster-based platform for confocal laser… read more here.
Keywords: active targeting; photodynamic therapy; endomicroscopy guided; guided photothermal ... See more keywords
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.045
Abstract: This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected… read more here.
Keywords: active targeting; nanoparticle assemblies; methyl mannopyranoside; lipid nanoparticle ... See more keywords
Insights into active targeting of nanoparticles in drug delivery: advances in clinical studies and design considerations for cancer nanomedicine.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00456
Abstract: Nanomedicine is a promising strategy for improving clinical outcomes for cancer therapies, by improving drug efficacy through enhanced delivery to disease sites. It is of importance for ultimate clinical success to consider the contributing factors… read more here.
Keywords: active targeting; drug delivery; delivery; chemistry ... See more keywords
Controlling Conjugated Antibodies at the Molecular Level for Active Targeting Nanoparticles toward HER2-Positive Cancer Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01090
Abstract: For active targeting nanodrug delivery systems conjugated with antibodies, both lack of control of the antibody at the molecular level and protein corona formation remarkably decreases targeting efficacy. Herein, we designed a series of silica… read more here.
Keywords: active targeting; her2 positive; molecular level; density ... See more keywords
A multifunctional lipid incorporating active targeting and dual-control release capabilities for precision drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b14470
Abstract: Active targeting and precise control of drug release based on nanoparticle-based therapies are urgently required to precisely treat cancer. We have custom synthesized a functional lipid (termed Fa-ONB) by introducing a folic acid targeting group… read more here.
Keywords: active targeting; control; drug; release capabilities ... See more keywords
Honokiol-loaded polymeric nanoparticles: an active targeting drug delivery system for the treatment of nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2017.1303854
Abstract: Abstract The purpose of this study was to develop a novel drug delivery system for a sustained and targeted delivery of honokiol (HK) to the nasopharyngeal carcinoma (NPC) HNE-1 cell lines, since the folate receptor… read more here.
Keywords: active targeting; delivery system; drug delivery; delivery ... See more keywords
Active Targeting of Drugs and Bioactive Molecules via Oral Administration by Ligand-Conjugated Lipidic Nanocarriers: Recent Advances
Sign Up to like & getrecommendations! Published in 2018 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-018-1262-2
Abstract: The oral route is the most widely accepted and commonly used route for administration. However, this route may not be suitable for certain drug candidates which suffer from the problem of low aqueous solubility and… read more here.
Keywords: active targeting; bioactive molecules; lipidic nanocarriers; ligand conjugated ... See more keywords
In vivo active-targeting fluorescence molecular imaging with adaptive background fluorescence subtraction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1130155
Abstract: Using active tumor-targeting nanoparticles, fluorescence imaging can provide highly sensitive and specific tumor detection, and precisely guide radiation in translational radiotherapy study. However, the inevitable presence of non-specific nanoparticle uptake throughout the body can result… read more here.
Keywords: active targeting; background; background fluorescence; fluorescence subtraction ... See more keywords
Tumor Chemo-Radiotherapy with Rod-Shaped and Spherical Gold Nano Probes: Shape and Active Targeting Both Matter
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.30523
Abstract: The morphologies of gold nanoparticles (NPs) affect their tumor accumulation through enhanced permeability and retention effect. However, detailed information and mechanisms of NPs' characteristics affecting tumor accumulation are limited. The aim of this study is… read more here.
Keywords: active targeting; rod shaped; shape active; rgd 125ipt ... See more keywords