Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402158
Abstract: The major drawback of conventional chemotherapeutic treatment is the non‐specificity or inability to ascertain and target cancerous cells directly. In this study, an active targeting strategy that is poised to carry the anticancer agents to… read more here.
Keywords: cancer; ohas cts; delivery; delivery vehicles ... See more keywords
Overcoming the On‐Target Toxicity in Antibody‐Mediated Therapies via an Indirect Active Targeting Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206912
Abstract: Antibody‐based therapies could be led astray when target receptors are expressed on nontarget sites, and the on‐target toxicity poses critical challenges to clinical applications. Here, a biomimetic indirect active targeting (INTACT) strategy is proposed based… read more here.
Keywords: active targeting; strategy; target toxicity; indirect active ... See more keywords
Deconvolving Passive and Active Targeting of Liposomes Bearing LDL Receptor Binding Peptides Using the Zebrafish Embryo Model.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202310781
Abstract: Improving target versus off-target ratio in nanomedicine remains a major challenge for increasing drug bioavailability and reducing toxicity. Active targeting using ligands on nanoparticle surfaces is a key approach but has limited clinical success. A… read more here.
Keywords: using zebrafish; receptor; zebrafish embryo; embryo model ... See more keywords
Synthetic peptide-labelled micelles for active targeting of cells overexpressing EGF receptors
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02755-w
Abstract: The goal of nanomedicine is to transport drugs to pathological tissues, reducing side effects while increasing targeting and efficacy. Aggregates grafted by bioactive molecules act as the active targeting agents. Among bioactive molecules, peptides, which… read more here.
Keywords: active targeting; peptide; peptide labelled; cells overexpressing ... See more keywords
Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.05.030
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating malignancies in patients, and there is an urgent need for an effective treatment method. Herein, we report a novel gold nanocluster-based platform for confocal laser… read more here.
Keywords: active targeting; photodynamic therapy; endomicroscopy guided; guided photothermal ... See more keywords
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.045
Abstract: This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected… read more here.
Keywords: active targeting; nanoparticle assemblies; methyl mannopyranoside; lipid nanoparticle ... See more keywords
Insights into active targeting of nanoparticles in drug delivery: advances in clinical studies and design considerations for cancer nanomedicine.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00456
Abstract: Nanomedicine is a promising strategy for improving clinical outcomes for cancer therapies, by improving drug efficacy through enhanced delivery to disease sites. It is of importance for ultimate clinical success to consider the contributing factors… read more here.
Keywords: active targeting; drug delivery; delivery; chemistry ... See more keywords
Controlling Conjugated Antibodies at the Molecular Level for Active Targeting Nanoparticles toward HER2-Positive Cancer Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c01090
Abstract: For active targeting nanodrug delivery systems conjugated with antibodies, both lack of control of the antibody at the molecular level and protein corona formation remarkably decreases targeting efficacy. Herein, we designed a series of silica… read more here.
Keywords: active targeting; her2 positive; molecular level; density ... See more keywords
A multifunctional lipid incorporating active targeting and dual-control release capabilities for precision drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b14470
Abstract: Active targeting and precise control of drug release based on nanoparticle-based therapies are urgently required to precisely treat cancer. We have custom synthesized a functional lipid (termed Fa-ONB) by introducing a folic acid targeting group… read more here.
Keywords: active targeting; control; drug; release capabilities ... See more keywords
Overcoming Hepatic Biotransformation Barrier of Gold Nanoparticles via Au-Se Bond for Enhanced In Vivo Active Targeting.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c10700
Abstract: As a key metabolic function of the liver, the hepatic biotransformation process can alter the predesigned surface chemistry of nanoparticles in vivo, leading to hampered functionality and targeting ability. However, strategies to modulate the hepatic… read more here.
Keywords: biotransformation; active targeting; hepatic biotransformation; gold nanoparticles ... See more keywords
Design of colloidal vectors for active targeting via complexation of biotinylated copolymers with gadolinium ions.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr00986c
Abstract: This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting.… read more here.
Keywords: gadolinium ions; vectors active; active targeting; design colloidal ... See more keywords