Sensitivity of subcellular components of neuromuscular junctions to decreased neuromuscular activity
Sign Up to like & getrecommendations! Published in 2021 at "Synapse"
DOI: 10.1002/syn.22220
Abstract: Muscle unloading imparts subtotal disuse on the neuromuscular system resulting in reduced performance capacity. This loss of function, at least in part, can be attributed to disruptions at the neuromuscular junction (NMJ). However, research has… read more here.
Keywords: zone; sensitivity subcellular; neuromuscular activity; active zone ... See more keywords
Intracellular protein complexes involved in synapse assembly in presynaptic neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2018.11.008
Abstract: The presynaptic active zone, composed of evolutionarily conserved protein complexes, is a specialized area that serves to orchestrate precise and efficient neurotransmitter release by organizing various presynaptic proteins involved in mediating docking and priming of… read more here.
Keywords: protein complexes; involved synapse; active zone; intracellular protein ... See more keywords
Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.06.017
Abstract: Background Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca2+-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into… read more here.
Keywords: active zone; secretion; insulin secretion; membrane ... See more keywords
How to maintain active zone integrity during high-frequency transmission
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.10.013
Abstract: In the central nervous system, the frequency at which reliable synaptic transmission can be maintained varies strongly between different types of synapses. Several pre- and postsynaptic processes must interact to enable high-frequency synaptic transmission. One… read more here.
Keywords: high frequency; transmission; frequency; integrity ... See more keywords
RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.03.011
Abstract: Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates… read more here.
Keywords: c2b; presynaptic active; rim c2b; active zone ... See more keywords
Resolving the molecular architecture of the photoreceptor active zone with 3D-MINFLUX
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl7560
Abstract: Cells assemble macromolecular complexes into scaffoldings that serve as substrates for catalytic processes. Years of molecular neurobiology research indicate that neurotransmission depends on such optimization strategies. However, the molecular topography of the presynaptic active zone… read more here.
Keywords: active zone; architecture photoreceptor; minflux; zone ... See more keywords
The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002030
Abstract: Autophagy is essential for cellular homeostasis and function. In neurons, autophagosome biogenesis is temporally and spatially regulated to occur near presynaptic sites, in part via the trafficking of autophagy transmembrane protein ATG-9. The molecules that… read more here.
Keywords: sorting atg; active zone; presynaptic autophagy; zone ... See more keywords
Sentryn Acts with a Subset of Active Zone Proteins To Optimize the Localization of Synaptic Vesicles in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.301466
Abstract: Synaptic vesicles (SVs) transmit signals by releasing neurotransmitters from specialized synaptic regions of neurons. In the synaptic region, SVs are tightly clustered around small structures called active zones. The motor KIF1A transports SVs outward through… read more here.
Keywords: zone; synaptic vesicles; svs; transport ... See more keywords
Active Zone of Permanent Magnet Synchronous Machine with a Non-Overlapping Concentrated Winding
Sign Up to like & getrecommendations! Published in 2018 at "Latvian Journal of Physics and Technical Sciences"
DOI: 10.2478/lpts-2018-0024
Abstract: Abstract The research is devoted to the investigation of NdFeB permanent magnet (PM) based synchronous generators with non-overlapping concentrated windings. The rotor of such a generator has 10 pole pairs (PMs), which is dictated by… read more here.
Keywords: permanent magnet; overlapping concentrated; zone permanent; active zone ... See more keywords
Nanoscopical Analysis Reveals an Orderly Arrangement of the Presynaptic Scaffold Protein Bassoon at the Golgi-Apparatus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.744034
Abstract: Bassoon is a core scaffold protein of the presynaptic active zone. In brain synapses, the C-terminus of Bassoon is oriented toward the plasma membrane and its N-terminus is oriented toward synaptic vesicles. At the Golgi-apparatus,… read more here.
Keywords: active zone; terminus; bassoon; golgi apparatus ... See more keywords
Hypothesis Relating the Structure, Biochemistry and Function of Active Zone Material Macromolecules at a Neuromuscular Junction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.798225
Abstract: This report integrates knowledge of in situ macromolecular structures and synaptic protein biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking events (i.e., docking, priming, Ca2+-triggering, and membrane fusion) that lead… read more here.
Keywords: hypothesis; active zone; biochemistry; zone material ... See more keywords